Rahimli Laman, Salmanton-García Jon, Kasper Philipp, Simon Michaela, Cornely Oliver A, Stemler Jannik
Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University Hospital Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany.
Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), University Hospital Cologne, Faculty of Medicine), University of Cologne, Cologne, Germany.
Med Mycol Case Rep. 2024 Feb 20;43:100636. doi: 10.1016/j.mmcr.2024.100636. eCollection 2024 Mar.
We report on a 64-year-old man with necrotizing pancreatitis related, invasive candidiasis, and candidemia. Despite a multidisciplinary management including antifungal therapy, endoscopic interventions and surgery, the patients' infection progressed and lead to colon perforation, retroperitoneal abscess formation, and polymicrobial bloodstream infections. Resistance to echinocandins in further complicated the course. This report emphasizes the need for vigilant monitoring and exploring alternative therapeutic approaches for patients in critical conditions.
我们报告了一名64岁男性，患有坏死性胰腺炎相关的侵袭性念珠菌病和念珠菌血症。尽管采取了包括抗真菌治疗、内镜干预和手术在内的多学科管理措施，但患者的感染仍在进展，导致结肠穿孔、腹膜后脓肿形成和多重微生物血流感染。对棘白菌素耐药进一步使病情复杂化。本报告强调了对危重症患者进行密切监测和探索替代治疗方法的必要性。
