Department of Microbiology and Immunology, College of Medical Technology, Chengdu University of Traditional Chinese Medicine , Chengdu, China.
Shandong New Hope Liuhe Agriculture and Animal Husbandry Technology Co., Ltd , Dezhou, China.
mBio. 2023 Aug 31;14(4):e0102023. doi: 10.1128/mbio.01020-23. Epub 2023 Jul 12.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as the causative agent of the recent COVID-19 pandemic, continues representing one of the main health concerns worldwide. Autophagy, in addition to its role in cellular homeostasis and metabolism, plays an important part for the host antiviral immunity. However, viruses including SARS-CoV-2 have evolved diverse mechanisms to not only overcome autophagy's antiviral pressure but also manipulate its machinery in order to enhance viral replication and propagation. Here, we discuss our current knowledge on the impact that autophagy exerts on SARS-CoV-2 replication, as well as the different counteracting measures that this virus has developed to manipulate autophagy's complex machinery. Some of the elements regarding this interplay may become future therapeutic targets in the fight against SARS-CoV-2.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）是导致近期 COVID-19 大流行的病原体，它仍然是全球主要的健康关注点之一。自噬除了在细胞内稳态和代谢中发挥作用外，还在宿主抗病毒免疫中起着重要作用。然而，包括 SARS-CoV-2 在内的病毒已经进化出多种机制，不仅可以克服自噬的抗病毒压力，还可以操纵其机制来增强病毒的复制和传播。在这里，我们讨论了自噬对 SARS-CoV-2 复制的影响，以及该病毒为操纵自噬的复杂机制而开发的不同对抗措施。关于这种相互作用的一些因素可能成为对抗 SARS-CoV-2 的未来治疗靶点。
