From the Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah, Kingdom of Saudi Arabia.
Saudi Med J. 2024 Mar;45(3):223-229. doi: 10.15537/smj.2024.45.3.20230873.
Lung cancer is a complicated and challenging disease and is one of the most common causes of cancer-related mortality worldwide. Within the lung microenvironment, specific cytokines, including the B cell activation factor (BAFF) and the A proliferation-inducing ligand (APRIL), are produce by various cells, notably airway epithelial cells, in response allergic inflammation or pulmonary infection. These cytokines play a critical role in maintaining local immune responses and fostering the survival of immune cells. The BAFF and APRIL system have been connected in a range of malignancies and have shown their potential in inducing drug resistance and promoting cancer progression. This review highlights recent studies on the involvement of BAFF and APRIL in various cancers, focusing mainly on their role in lung cancer, and discusses the possibility of these molecules in contributing to drug resistance and cancer progression following pulmonary infection. We suggest consideration the targeting BAFF and APRIL or their respective receptors as promising novel therapies for effective treatment of lung cancer, especially post pulmonary infection. However, it remains important to conduct further investigations to fully elucidate the precise mechanisms underlying how the BAFF and APRIL systems enhance cancer survival and drug resistance subsequent pulmonary infections.
肺癌是一种复杂且具有挑战性的疾病，是全球癌症相关死亡的最常见原因之一。在肺部微环境中，特定的细胞因子，包括 B 细胞激活因子 (BAFF) 和增殖诱导配体 (APRIL)，由各种细胞产生，特别是气道上皮细胞，以响应过敏炎症或肺部感染。这些细胞因子在维持局部免疫反应和促进免疫细胞存活方面发挥着关键作用。BAFF 和 APRIL 系统已在多种恶性肿瘤中被联系起来，并显示出它们在诱导耐药性和促进癌症进展方面的潜力。这篇综述强调了最近关于 BAFF 和 APRIL 参与各种癌症的研究，主要集中在它们在肺癌中的作用，并讨论了这些分子在肺部感染后导致耐药性和癌症进展中的可能性。我们建议考虑靶向 BAFF 和 APRIL 或它们各自的受体作为治疗肺癌的有前途的新疗法，特别是在肺部感染后。然而，仍然需要进行进一步的研究，以充分阐明 BAFF 和 APRIL 系统如何增强癌症存活和耐药性以及随后的肺部感染的确切机制。
