Department of Neurology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia.
Department of Neurology, Dr. Sardjito General Hospital, Yogyakarta, 55281, Indonesia.
Sci Rep. 2024 Mar 4;14(1):5281. doi: 10.1038/s41598-024-56023-3.
Although medial temporal atrophy (MTA) and parietal atrophy (Koedam score) have been used to diagnose Alzheimer's disease (AD), early detection of other dementia types remains elusive. The study aims to investigate the association between these brain imaging markers and cognitive function in dementia. This cross-sectional study collected data from the Memory Clinic of Dr. Sardjito General Hospital Yogyakarta, Indonesia from January 2020 until December 2022. The cut-off value of MTA and Koedam score was set with Receiver Operating Curve. Multivariate analysis was performed to investigate the association between MTA and Koedam score with cognitive function. Of 61 patients, 22.95% had probable AD, 59.01% vascular dementia, and 18.03% mixed dementia. Correlation test showed that MTA and Koedam score were negatively associated with Montreal Cognitive Assessment-Indonesian Version (MoCA-INA) score. MTA score ≥ 3 (AUC 0.69) and Koedam score ≥ 2 (AUC 0.67) were independently associated with higher risk of poor cognitive function (OR 13.54, 95% CI 1.77-103.43, p = 0.01 and OR 5.52, 95% CI 1.08-28.19, p = 0.04). Higher MTA and Koedam score indicate worse cognitive function in dementia. Future study is needed to delineate these findings as prognostic markers of dementia severity.
虽然内侧颞叶萎缩（MTA）和顶叶萎缩（Koedam 评分）已被用于诊断阿尔茨海默病（AD），但其他类型痴呆的早期检测仍然难以实现。本研究旨在探讨这些脑影像学标志物与痴呆患者认知功能之间的关系。本横断面研究收集了 2020 年 1 月至 2022 年 12 月期间印度尼西亚日惹萨达尔吉托综合医院记忆诊所的数据。采用受试者工作特征曲线（ROC）确定 MTA 和 Koedam 评分的截断值。采用多元分析研究 MTA 和 Koedam 评分与认知功能之间的关系。在 61 例患者中，22.95%为可能的 AD，59.01%为血管性痴呆，18.03%为混合性痴呆。相关性检验表明，MTA 和 Koedam 评分与印度尼西亚蒙特利尔认知评估量表（MoCA-INA）评分呈负相关。MTA 评分≥3（AUC 0.69）和 Koedam 评分≥2（AUC 0.67）与认知功能差的风险增加独立相关（OR 13.54，95%CI 1.77-103.43，p=0.01 和 OR 5.52，95%CI 1.08-28.19，p=0.04）。较高的 MTA 和 Koedam 评分表明痴呆患者的认知功能更差。未来的研究需要进一步阐明这些发现，以作为痴呆严重程度的预后标志物。
