Pandiar Deepak, Anbumani P, Krishnan Reshma Poothakulath
Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu India.
Oral and Maxillofacial Surgeon, 115, Vellam Thangiya Pillayar Kovil street, Tirunelveli town, Tirunelveli, Tamil Nadu India.
Indian J Otolaryngol Head Neck Surg. 2024 Feb;76(1):1054-1061. doi: 10.1007/s12070-023-04110-8. Epub 2023 Aug 7.
Non-ossifying fibroma (NOF) of jaw bones are rare. While NOF is the most common benign bone tumor of long bones with pathognomonic radiological features and bear a tendency for self-regression, gnathic NOF appears to be comparatively larger in size and behave more aggressively. A 16 years old female patient reported with painless swelling of the right side of the face of 4 months duration. Radiographic analysis showed a unilocular radiolucent lesion of right angle of the mandible with ill-defined margins, cortical perforation and thinning of inferior border. The lesion was provisionally diagnosed as odontogenic keratocyst/unicystic ameloblastoma and incisional biopsy was performed. The histopathological features and immunohistochemical characteristics favored a diagnosis of NOF. The lesion was excised and reconstructed. The excised specimen confirmed the diagnosis. There are no signs of recurrence at 18 months follow-up. NOF should be considered in the differential diagnosis of uni-/multilocular radiolucencies of jaws particularly the posterior mandible.
颌骨非骨化性纤维瘤（NOF）较为罕见。虽然NOF是长骨最常见的良性骨肿瘤，具有特征性的放射学表现且有自行消退的倾向，但颌骨NOF似乎体积相对较大且行为更具侵袭性。一名16岁女性患者报告右侧面部无痛性肿胀4个月。影像学分析显示下颌骨右角有一单房性透射性病变，边界不清，皮质穿孔，下缘变薄。该病变初步诊断为牙源性角化囊肿/单囊性成釉细胞瘤，并进行了切开活检。组织病理学特征和免疫组化特征支持NOF的诊断。病变被切除并重建。切除的标本证实了诊断。随访18个月无复发迹象。在颌骨单房/多房透射性病变的鉴别诊断中，尤其是下颌骨后部，应考虑NOF。
