Gao Xihai, Ran Deshui, Zhong Bao, Han Jingchao
Binzhou Polytechnic, Binzhou, Shandong Province, China.
Department of Radiology, Jinan Second Hospital, Jinan, Shandong Province, China.
Medicine (Baltimore). 2025 Sep 5;104(36):e44185. doi: 10.1097/MD.0000000000044185.
Nonossifying fibroma (NOF) is one of the benign bone tumors in adolescents, and it rarely occurs in the jawbone. According to the site of onset, it is divided into the cortical type and the medullary type. Currently, there is no case report of medullary NOF in the mandible of the elderly. Through the description of the diagnosis and treatment experience of this case, combined with literature analysis, it provides help for clinical diagnosis and treatment.
The patient was a 69-year-old male who was treated for discomfort due to distension in the right mandibular first molar area. Clinical data collected in the past 10 years showed that the lesion grew slowly, and the imaging findings showed that the alveolar bone in the right mandibular first molar area showed uniform low-density imaging, the maxillary bone plate was locally eroded and damaged, and the lingual bone plate was significantly thinned.
Pathological sections showed that the lesions were mainly composed of a large amount of fibrous tissue, and the proliferated benign fibroblasts were arranged in a matted or swirling structure, in line with NOF manifestations.
The tumor was completely scraped off by surgical methods, and pathological examination was conducted.
No discomfort was found at the surgical site during postoperative follow-up.
The incidence of NOF in the mandible of the elderly is extremely rare. It has a long growth cycle and no obvious clinical symptoms. Clinical diagnosis requires a full combination of imaging and pathology. Especially for the medullary type of NOF, the imaging manifestation is not characterized by cortical bone defect, but rather shows a tumor-like manifestation with uniformly low density similar to fibrous tissue. It has a certain invasiveness to the bone plate of the mandible. Surgical treatment should be carried out when necessary, and regular postoperative follow-up should be conducted.
摘要 理论依据:非骨化性纤维瘤(NOF)是青少年常见的良性骨肿瘤之一,在颌骨中很少见。根据发病部位可分为皮质型和髓质型。目前,尚无老年患者下颌骨髓质型NOF的病例报道。通过对该病例诊治经验的描述,并结合文献分析,为临床诊治提供帮助。
患者为69岁男性,因右下颌第一磨牙区胀痛不适前来就诊。过去10年收集的临床资料显示,病变生长缓慢,影像学表现为右下颌第一磨牙区牙槽骨呈均匀低密度影,上颌骨板局部侵蚀破坏,舌侧骨板明显变薄。
病理切片显示病变主要由大量纤维组织构成,增生的良性成纤维细胞呈束状或漩涡状排列,符合NOF表现。
采用手术方法将肿瘤完整刮除,并进行病理检查。
术后随访期间手术部位未发现不适。
老年患者下颌骨NOF发病率极低。其生长周期长,无明显临床症状。临床诊断需影像学与病理学充分结合。尤其是髓质型NOF,影像学表现并非以皮质骨缺损为特征,而是呈现类似纤维组织的均匀低密度肿瘤样表现。对下颌骨骨板有一定侵袭性。必要时应行手术治疗,并定期进行术后随访。