Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Microbiol Mol Biol Rev. 2024 Mar 27;88(1):e0019623. doi: 10.1128/mmbr.00196-23. Epub 2024 Mar 5.
SUMMARYSpores are primary infectious propagules for the majority of human fungal pathogens; however, relatively little is known about their fundamental biology. One strategy to address this deficiency has been to develop the basidiospores of into a model for pathogenic spore biology. Here, we provide an update on the state of the field with a comprehensive review of the data generated from the study of basidiospores from their formation (sporulation) and differentiation (germination) to their roles in pathogenesis. Importantly, we provide support for the presence of basidiospores in nature, define the key characteristics that distinguish basidiospores from yeast cells, and clarify their likely roles as infectious particles. This review is intended to demonstrate the importance of basidiospores in the field of research and provide a solid foundation from which researchers who wish to study sexual spores in any fungal system can launch their studies.
摘要
孢子是大多数人类真菌病原体的主要感染传播体;然而，人们对它们的基础生物学知之甚少。解决这一不足的一种策略是将 的担孢子发展成为致病孢子生物学的模型。在这里，我们全面回顾了从形成（孢子形成）到分化（萌发）到在发病机制中的作用的 担孢子的研究数据，提供了该领域的最新进展。重要的是，我们为自然界中存在担孢子提供了支持，定义了将担孢子与酵母细胞区分开来的关键特征，并阐明了它们作为感染性颗粒的可能作用。本综述旨在展示担孢子在 研究领域的重要性，并为希望在任何真菌系统中研究有性孢子的研究人员提供坚实的基础，以便他们开展研究。
