Department of Neurology, Shanghai Pudong New Area People's Hospital, Shanghai, China.
Department of Image, Shanghai Pudong New Area People's Hospital, Shanghai, China.
Neurol India. 2024 Jan 1;72(1):64-68. doi: 10.4103/ni.ni_211_22. Epub 2024 Feb 29.
Previous literature has reported that red cell distribution width (RDW) correlated with Alzheimer's disease (AD), but the correlation with mild cognitive impairment (MCI) was not clear. This study aimed to investigate MCI in the residents aged ≥65 living in the suburban of Shanghai, China.
A total of 550 participants were recruited as MCI (MCI group, 226) and normal (NC group, 284) groups and received blood examination voluntarily. Blood routine indexes were tested by blood tests using Sysmex XT-4000i (Japan). The Chi-square test, t-test, and linear regression analysis were used to find the statistical difference and correlation of data, respectively.
Each cognition domain of MCI was found to be impaired, the weight of which, however, was different in integral damage. Most MCI people had impairment of attention among cognitive domains (235, 88.3%). According to the results of the binary logistic regression, the highest weight among impaired cognitive domains was for attention in MCI, and the Wald value of attention was higher than those of others (Wald = 51.83). Additionally, RDW had the greatest negative correlation with attention score (P < 0.05).
Increased RDW may be considered as a biomarker of MCI.
既往文献报道红细胞分布宽度（RDW）与阿尔茨海默病（AD）相关，但与轻度认知障碍（MCI）的相关性尚不清楚。本研究旨在探讨中国上海郊区≥65 岁居民的 MCI。
共招募 550 名参与者作为 MCI（MCI 组，226 名）和正常（NC 组，284 名）组，并自愿接受血液检查。使用 Sysmex XT-4000i（日本）进行血液常规检查。采用卡方检验、t 检验和线性回归分析分别寻找数据的统计学差异和相关性。
MCI 的每个认知域均存在受损，但其整体损害的权重不同。在认知域中，大多数 MCI 患者的注意力受损（235 例，88.3%）。根据二元逻辑回归的结果，MCI 中受损认知域的权重最高的是注意力，注意力的 Wald 值高于其他值（Wald=51.83）。此外，RDW 与注意力评分呈最大负相关（P<0.05）。
RDW 升高可作为 MCI 的生物标志物。
