Jiang Minggeng, Hong Shicong, Li Yingying, Zhu Xiaoxiao
The Third People's Hospital of Liaocheng City, Liaocheng, Shandong Province, China.
Medicine (Baltimore). 2025 May 9;104(19):e42365. doi: 10.1097/MD.0000000000042365.
This study aimed to investigate the potential association between the hemoglobin-to-red blood cell distribution width ratio (HRR) and cognitive impairment in a representative sample of elderly Americans. Data from National Health and Nutrition Examination Survey 1999 to 2002 were utilized to analyze demographic information, cognitive function assessments, and laboratory data. Binary Logistic regression was conducted to analyze the associations. Subgroup analyses and sensitivity analyses were performed simultaneously. In the univariable logistic regression analysis, the odds ratio was 0.13 (95% confidence interval [CI]: 0.06-0.25; P < .001). After adjusting for all covariates in the multivariable regression analysis, the odds ratio was 0.25 (95% CI: 0.11-0.6; P = .002). Compared to the lowest HRR group, the higher HRR groups had significantly lower odds of cognitive impairment: Q2 (OR = 0.6, 95% CI: 0.42-0.84, P = .003), Q3 (OR = 0.54, 95% CI: 0.37-0.77, P = .001), and Q4 (OR = 0.56, 95% CI: 0.38-0.82, P = .003). Subgroup and sensitivity results were stable and consistent. These results suggest that higher levels of HRR may be associated with a lower risk of cognitive impairment in elderly Americans.
本研究旨在调查血红蛋白与红细胞分布宽度比值（HRR）与美国老年代表性样本认知障碍之间的潜在关联。利用1999年至2002年国家健康与营养检查调查的数据来分析人口统计学信息、认知功能评估和实验室数据。进行二元逻辑回归分析以分析关联。同时进行亚组分析和敏感性分析。在单变量逻辑回归分析中，比值比为0.13（95%置信区间[CI]：0.06 - 0.25；P <.001）。在多变量回归分析中对所有协变量进行调整后，比值比为0.25（95% CI：0.11 - 0.6；P =.002）。与最低HRR组相比，较高HRR组认知障碍的几率显著更低：Q2（OR = 0.6，95% CI：0.42 - 0.84，P =.003），Q3（OR = 0.54，95% CI：0.37 - 0.77，P =.001），以及Q4（OR = 0.56，95% CI：0.38 - 0.82，P =.003）。亚组和敏感性结果稳定且一致。这些结果表明，较高水平的HRR可能与美国老年人认知障碍风险较低相关。
