College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Jilin Provincial International Joint Research Center for the Development and Utilization of Authentic Medicinal Materials, Changchun, China.
J Sci Food Agric. 2024 Aug 15;104(10):6085-6099. doi: 10.1002/jsfa.13440. Epub 2024 Mar 19.
Red Panax notoginseng (RPN) is one of the major processed products of P. notoginseng (PN), with more effective biological activities. However, the traditional processing method of RPN has some disadvantages, such as low conversion rate of ginsenosides and long processing time.
In this work, we developed a green, safe, and efficient approach for RPN processing by aspartic acid impregnation pretreatment. Our results showed that the optimized temperature, steaming time, and concentration of aspartic acid were 120 °C, 1 h, and 3% respectively. The original ginsenosides in PN treated by aspartic acid (Asp-PN) were completely converted to rare saponins at 120 °C within just 1 h. The concentration of the rare ginsenosides in Asp-PN was two times higher than that in untreated RPN. In addition, we examined the protective effect of RPN and Asp-PN on acetaminophen-induced liver injury in a mouse model. The results showed that Asp-PN has significantly more potent hepatoprotective action than the RPN. The hepatoprotection of Asp-PN in acetaminophen-induced hepatotoxicity may be due to its anti-oxidative stress, anti-apoptotic, and anti-inflammatory activities.
These results indicated that aspartic acid impregnation pretreatment may provide an effective method to shorten the steaming time, improve the conversion rate of ginsenosides, and enhance hepatoprotective activity of RPN. © 2024 Society of Chemical Industry.
红参是三七（PN）的主要加工产品之一，具有更强的生物活性。然而，红参的传统加工方法存在一些缺点，如人参皂苷转化率低和加工时间长。
在这项工作中，我们通过天冬氨酸浸渍预处理开发了一种绿色、安全、高效的红参加工方法。结果表明，优化的温度、蒸制时间和天冬氨酸浓度分别为 120°C、1 小时和 3%。在 120°C 下，经过天冬氨酸处理的 PN 中原有的人参皂苷在短短 1 小时内完全转化为罕见的皂苷。Asp-PN 中罕见人参皂苷的浓度是未处理 RPN 的两倍。此外，我们在小鼠模型中研究了 RPN 和 Asp-PN 对乙酰氨基酚诱导的肝损伤的保护作用。结果表明，Asp-PN 比 RPN 具有更强的肝保护作用。Asp-PN 在对乙酰氨基酚诱导的肝毒性中的保肝作用可能与其抗氧化应激、抗细胞凋亡和抗炎作用有关。
这些结果表明，天冬氨酸浸渍预处理可能为缩短蒸制时间、提高人参皂苷转化率和增强红参的肝保护活性提供一种有效方法。© 2024 化学工业协会。
