School of Pharmacy, Minzu University of China, 27 Zhongguancun South Street, Beijing 100081, China; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.
Fitoterapia. 2024 Oct;178:106159. doi: 10.1016/j.fitote.2024.106159. Epub 2024 Aug 8.
Five previously undescribed protopanaxatriol-type saponins, notoginsenosides Ta-Te (1-5), together with eighteen known triterpenoid saponins (6-23) were isolated from the roots of Panax notoginseng. The structures of new compounds were determined by HRESIMS and NMR spectroscopic analyses and chemical methods. Compounds 1 and 2 were the first examples of ginsenosides featuring a 6-deoxy-β-d-glucose moiety from Panax species. Compounds 1-4, 7, 10, 12, 21-22 showed protective effects on L02 cells against the injury of acetaminophen (APAP). Among them, notoginsenoside R1 (12), ginsenoside Rg1 (21), and ginsenoside Re (22) were the most potent ones, with cell viabilities >80%. Moreover, compounds 12 and 22 remarkably alleviated APAP-induced liver injury in mice. These saponins are potential hepatoprotective agents.
从三七的根部分离得到了五个以前未描述的原人参三醇型皂苷，即 notoginsenosides Ta-Te（1-5），以及十八个已知的三萜皂苷（6-23）。新化合物的结构通过高分辨率质谱（HRESIMS）和 NMR 波谱分析以及化学方法确定。化合物 1 和 2 是来自 Panax 属的首次具有 6-去氧-β-d-葡萄糖部分的人参皂苷。化合物 1-4、7、10、12、21-22 对乙酰胺酚（APAP）引起的 L02 细胞损伤具有保护作用。其中，人参皂苷 R1（12）、人参皂苷 Rg1（21）和人参皂苷 Re（22）的活性最强，细胞活力>80%。此外，化合物 12 和 22 显著减轻了 APAP 诱导的小鼠肝损伤。这些皂苷是潜在的肝保护剂。
