Molecular Biology Division, Bhabha Atomic Research Centre, Mumbai, India.
Schools of Life Sciences, Homi Bhabha National Institute (DAE-Deemed University), Mumbai, India.
J Bacteriol. 2024 Apr 18;206(4):e0000624. doi: 10.1128/jb.00006-24. Epub 2024 Mar 6.
Bacterial biofilms are intricate ecosystems of microbial communities that adhere to various surfaces and are enveloped by an extracellular matrix composed of polymeric substances. Within the context of bacterial biofilms, extracellular DNA (eDNA) originates from cell lysis or is actively secreted, where it exerts a significant influence on the formation, stability, and resistance of biofilms to environmental stressors. The exploration of eDNA within bacterial biofilms holds paramount importance in research, with far-reaching implications for both human health and the environment. An enhanced understanding of the functions of eDNA in biofilm formation and antibiotic resistance could inspire the development of strategies to combat biofilm-related infections and improve the management of antibiotic resistance. This comprehensive review encapsulates the latest discoveries concerning eDNA, encompassing its origins, functions within bacterial biofilms, and significance in bacterial pathogenesis.
细菌生物膜是微生物群落的复杂生态系统，它们附着在各种表面上，并被由聚合物质组成的细胞外基质所包围。在细菌生物膜的背景下，细胞外 DNA（eDNA）源自细胞裂解或主动分泌，对生物膜的形成、稳定性和对环境胁迫的抵抗力产生重大影响。探索细菌生物膜中的 eDNA 在研究中至关重要，对人类健康和环境都有着深远的影响。深入了解 eDNA 在生物膜形成和抗生素耐药性中的功能，可以激发对抗生物膜相关感染的策略的发展，并改善抗生素耐药性的管理。本综述总结了有关 eDNA 的最新发现，包括其起源、在细菌生物膜中的功能以及在细菌发病机制中的意义。
