运动后肌肉干细胞调控的性别差异

Sex-Based Differences in Muscle Stem Cell Regulation Following Exercise.

机构信息

School of Human Kinetics , Department of Cellular and Molecular Medicine, Regenerative Medicine Program, Centre on Neuromuscular Disease , University of Ottawa, Ottawa, Ontario, Canada.

出版信息

Exerc Sport Sci Rev. 2024 Jul 1;52(3):87-94. doi: 10.1249/JES.0000000000000337. Epub 2024 Mar 6.

DOI:10.1249/JES.0000000000000337

PMID:38445901

Abstract

Sexual dimorphism, driven by the sex hormones testosterone and estrogen, influences body composition, muscle fiber type, and inflammation. Research related to muscle stem cell (MuSC) responses to exercise has mainly focused on males. We propose a novel hypothesis that there are sex-based differences in MuSC regulation following exercise, such that males have more MuSCs, whereas females demonstrate a greater capacity for regeneration.

摘要

性二态性受雄激素睾酮和雌激素的驱动，影响身体成分、肌肉纤维类型和炎症。与运动对肌肉干细胞（MuSC）反应相关的研究主要集中在男性上。我们提出了一个新的假设，即运动后 MuSC 的调节存在基于性别的差异，即男性拥有更多的 MuSCs，而女性则表现出更大的再生能力。