Deberdt R
Postgrad Med J. 1979;55 Suppl 1:48-9.
Twenty chronic schizophrenic inpatients who were being treated with high doses of neuroleptics and of whom seven had extra-pyramidal symptoms in spite of anti-Parkinsonian therapy, were given oral domperidone (50 mg t.d.s. for 2 weeks) for the relief of chronic dyspepsia. The dyspepsia symptoms were markedly improved, no side effects were seen and, even at high doses, domperidone did not intensify the existing extra-pyramidal side effects of the neuroleptics or produce new ones.
20名正在接受大剂量抗精神病药物治疗的慢性精神分裂症住院患者，其中7名尽管接受了抗帕金森治疗仍有锥体外系症状，给予口服多潘立酮（每日3次，每次50毫克，共2周）以缓解慢性消化不良。消化不良症状明显改善，未观察到副作用，即使在高剂量下，多潘立酮也未加重抗精神病药物现有的锥体外系副作用或产生新的副作用。
