Yurasakpong Laphatrada, Suwannakhan Athikhun, Iwanaga Joe, Tubbs R Shane, Chaiyamoon Arada, Kruepunga Nutmethee, Asuvapongpatana Somluk, Sudsang Thanwa
Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, Thailand.
In Silico and Clinical Anatomy Research Group (iSCAN), Bangkok, Thailand, Thailand.
Anat Cell Biol. 2024 Sep 30;57(3):473-475. doi: 10.5115/acb.23.289. Epub 2024 Mar 7.
Transverse basilar cleft (TBC) is an extremely rare variation of the clivus or the basilar part of the occipital bone. In this report, a unilateral transverse basilar fissure was found at the clivus in a head computed tomography of an 18-year-old female patient diagnosed with hemifacial microsomia (HFM). Image analysis of this patient showed shortening of the ramus of the right mandible along with medial displacement of the right temporomandibular joint and hypoplastic right maxilla. In addition, observation of the clivus showed a cleft between the basioticum and basioccipital bones at the level of the pharyngeal tubercle on the right side. This cleft was identified as TBC. Clival variations, TBC included, attributed to HFM have never been reported. This report draws attention to the complex relationship between abnormal development of clivus and HFM syndrome, and sheds light on a possible genetic and molecular association between these two conditions.
横行基底裂（TBC）是斜坡或枕骨基底部分极其罕见的变异。在本报告中，一名被诊断为半侧颜面短小畸形（HFM）的18岁女性患者的头部计算机断层扫描显示斜坡处存在单侧横行基底裂。对该患者的图像分析显示，右下颌骨升支缩短，同时右颞下颌关节向内侧移位，右侧上颌骨发育不全。此外，对斜坡的观察显示，在右侧咽结节水平的基底部和基枕骨之间存在一个裂隙。该裂隙被确定为TBC。包括TBC在内的斜坡变异与HFM的关系此前从未有过报道。本报告提请注意斜坡异常发育与HFM综合征之间的复杂关系，并揭示了这两种情况之间可能的遗传和分子关联。
