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天然产物多糖抗胃癌的活性成分及作用机制研究综述

Review on active components and mechanism of natural product polysaccharides against gastric carcinoma.

作者信息

Liu Xinze, Sun Kaijing, Jin Xin, Wu Xinmin, Xia Mingjie, Sun Ying, Feng Lin, Li Guangzhe, Wan Xilin, Chen Changbao

机构信息

Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, China.

Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, China.

出版信息

Heliyon. 2024 Feb 29;10(5):e27218. doi: 10.1016/j.heliyon.2024.e27218. eCollection 2024 Mar 15.

Abstract

One of the malignant tumors with a high occurrence rate worldwide is gastric carcinoma, which is an epithelial malignant tumor emerging from the stomach. Natural product polysaccharides are a kind of natural macromolecular polymers, which have the functions of regulating immunity, anti-oxidation, anti-fatigue, hypoglycemia, etc. Natural polysaccharides have remarkable effectiveness in preventing the onset, according to studies, and development of gastric cancer at both cellular and animal levels. This paper summarizes the inhibitory mechanisms and therapeutic significance of plant polysaccharides, fungi polysaccharides, and algal polysaccharides in natural product polysaccharides on the occurrence and development of gastric cancer in recent years, providing a theoretical basis for the research, development, and medicinal value of polysaccharides.

摘要

胃癌是全球发病率较高的恶性肿瘤之一,它是起源于胃部的上皮性恶性肿瘤。天然产物多糖是一类天然高分子聚合物,具有调节免疫、抗氧化、抗疲劳、降血糖等功能。据研究,天然多糖在细胞和动物水平上对预防胃癌的发生和发展具有显著效果。本文综述了天然产物多糖中的植物多糖、真菌多糖和藻类多糖近年来对胃癌发生发展的抑制机制及治疗意义,为多糖的研究、开发及其药用价值提供理论依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3082/10915412/a38eb4fa77ea/gr1.jpg

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