Directorate-General for Health Prevention, Ministry of Health, Rome, Italy.
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Front Public Health. 2024 Feb 21;12:1343509. doi: 10.3389/fpubh.2024.1343509. eCollection 2024.
Public health genomics (PHG) aims to integrate advances in genomic sciences into healthcare for the benefit of the general population. As in many countries, there are various research initiatives in this field in Italy, but a clear picture of the national research portfolio has never been sketched. Thus, we aimed to provide an overview of current PHG research projects at the national or international level by consultation with Italian institutional and academic experts. We included 68 PHG projects: the majority were international projects in which Italian researchers participated ( = 43), mainly funded by the European Commission, while the remainder were national initiatives ( = 25), mainly funded by central government. Funding varied considerably, from € 50,000 to € 80,803,177. Three main research themes were identified: governance ( = 20); precision medicine (PM; = 46); and precision public health ( = 2). We found that research activities are preferentially aimed at the clinical application of PM, while other efforts deal with the governance of the complex translation of genomic innovation into clinical and public health practice. To align such activities with national and international priorities, the development of an updated research agenda for PHG is needed.
公共卫生基因组学（PHG）旨在将基因组科学的进展整合到医疗保健中，造福于普通人群。与许多国家一样，意大利在该领域也有各种研究计划，但从未对国家研究组合有一个清晰的描述。因此，我们旨在通过咨询意大利机构和学术专家，提供当前 PHG 国家或国际层面研究项目的概述。我们共纳入了 68 个 PHG 项目：其中大多数是意大利研究人员参与的国际项目（ = 43），主要由欧盟委员会资助，其余为国家倡议（ = 25），主要由中央政府资助。资金数额差异很大，从 50,000 欧元到 80,803,177 欧元不等。确定了三个主要的研究主题：治理（ = 20）；精准医学（PM； = 46）；精准公共卫生（ = 2）。我们发现，研究活动主要侧重于 PM 的临床应用，而其他努力则涉及到基因组创新向临床和公共卫生实践复杂转化的治理。为了使这些活动与国家和国际优先事项保持一致，需要制定一个更新的 PHG 研究议程。
