限时进餐对2型糖尿病患者血糖控制和体重管理的影响：一项为期18个月的纵向研究。

The Impact of Time-Restricted Meal Intake on Glycemic Control and Weight Management in Type 2 Diabetes Mellitus Patients: An 18-Month Longitudinal Study.

作者信息

Rastogi Smriti, Verma Narsingh, Raghuwanshi Gourav S, Atam Virendra, Kumar Verma Dileep

机构信息

Physiology, King George's Medical University, Lucknow, IND.

Physiology, People's College of Medical Sciences and Research Centre, Bhopal, IND.

出版信息

Cureus. 2024 Feb 6;16(2):e53680. doi: 10.7759/cureus.53680. eCollection 2024 Feb.

DOI:10.7759/cureus.53680

PMID:38455801

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10918388/

Abstract

AIMS

This study aimed to investigate the impact of time-restricted meal intake (TRM) on anthropometric and biochemical parameters in patients with type 2 diabetes mellitus (T2DM).

METHODS

A total of 400 patients diagnosed with T2DM were selected from the Endocrinology Department at King George's Medical University (KGMU), Lucknow, based on the American Diabetes Association (ADA) guidelines and specific criteria. A total of 127 patients were lost to follow-up, resulting in 273 patients who completed the study. The patients were randomly assigned to two groups: the TRM group (consenting to have an early dinner at 7 pm) and the control group (non-TRM/late-night eater group). Baseline data were recorded, and follow-up assessments were conducted at six months, 12 months, and 18 months. Informed consent was obtained, and a diet chart was regularly maintained and updated.

RESULTS

The TRM group experienced a significant weight loss of 3.88 kg (5.45%) and a substantial reduction in BMI by 1.5 units (5.26%). In contrast, the non-TRM/control group had smaller reductions in weight (1.36 kg, 1.77%) and BMI (0.5 units, 1.65%). TRM group showed significant reductions in fasting blood sugar levels by 33.9 mg/dl (21.17%), postprandial blood sugar levels by 94.6 mg/dl (38.88%), and glycosylated hemoglobin (HbA1c) levels by 1.37 (15.87%). These improvements were significantly greater than the reductions observed in the control group, which had decreases of 29.3 mg/dl (17.85%) in fasting blood sugar levels, 41.6 mg/dl (16.84%) in postprandial blood sugar levels, and 0.59 (6.89%) in HbA1c levels.

CONCLUSION

Our findings underscore the potential of TRM as an effective strategy for weight management and glycemic control in patients with T2DM, even in a long-term context. These results support time-restricted eating as a sustainable lifestyle modification for managing chronic metabolic diseases.

摘要

目的

本研究旨在调查限时进餐（TRM）对2型糖尿病（T2DM）患者人体测量学和生化指标的影响。

方法

根据美国糖尿病协会（ADA）指南和特定标准，从勒克瑙乔治国王医科大学（KGMU）内分泌科选取了400例确诊为T2DM的患者。共有127例患者失访，最终273例患者完成了研究。患者被随机分为两组：TRM组（同意晚上7点提前吃晚餐）和对照组（非TRM/深夜进食组）。记录基线数据，并在6个月、12个月和18个月时进行随访评估。获得了知情同意书，并定期维护和更新饮食图表。

结果

TRM组体重显著减轻3.88千克（5.45%），BMI大幅降低1.5个单位（5.26%）。相比之下，非TRM/对照组体重减轻较少（1.36千克，1.77%），BMI降低较少（0.5个单位，1.65%）。TRM组空腹血糖水平显著降低33.9毫克/分升（21.17%），餐后血糖水平降低94.6毫克/分升（38.88%），糖化血红蛋白（HbA1c）水平降低1.37（15.87%）。这些改善显著大于对照组的降低幅度，对照组空腹血糖水平降低29.3毫克/分升（17.85%），餐后血糖水平降低41.6毫克/分升（16.84%），HbA1c水平降低0.59（6.89%）。