University of Maryland, Baltimore, MD, USA.
Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Nutr Diabetes. 2021 Jan 15;11(1):6. doi: 10.1038/s41387-021-00149-0.
Time restricted eating (TRE) is an emerging dietary intervention for weight loss that is hypothesized to reinforce the metabolic benefits of nightly fasting/ketosis. This pilot study investigated the effectiveness of a daily 14-h metabolic fast (14:10 TRE beginning after dinner, a "fasting snack" at hour 12, and ending with breakfast 14 h later) combined with a commercial weight management program on body weight and fasting blood glucose (FBG) in individuals with obesity. We also investigated the effect of the low-calorie, high-fat, low-carbohydrate, and low-protein "fasting snack" on blood glucose.
This 8-week, randomized, controlled, clinical trial included men and women (BMI ≥ 30 kg/m) between June and October 2020. Study procedures were conducted remotely. Participants were randomized to 14:10 or 12-h TRE (12:12, active comparator) and prescribed a diet (controlled for calories and macronutrient composition) and exercise program that included weekly customized counseling and support. The primary outcome was change from baseline in body weight in the 14:10 group.
Of the 78 randomized participants, 60 (n = 30/group) completed 8 weeks. The LS mean change from baseline in weight in the 14:10 group was -8.5% (95% CI -9.6 to -7.4; P < 0.001) and -7.1% (-8.3 to -5.8; P < 0.001) in the 12:12 group (between group difference -1.4%; -2.7 to -0.2; P < 0.05). There was a statistically significant LS mean change from baseline to week 8 in FBG in the 14:10 group of -7.6 mg/dl (95% CI -15.1 to -0.1; P < 0.05) but not in the 12:12 group (-3.1 mg/dl, -10.0 to 3.7; P = NS). Both interventions resulted in a larger reduction in FBG in participants with elevated FBG (≥100 mg/dl) at baseline (both P < 0.05).
In participants with obesity who completed 8 weeks of the 14:10 TRE schedule combined with a commercial weight loss program, there was statistically significant and clinically meaningful weight loss and improvements in FBG.
限时进食（TRE）是一种新兴的减肥饮食干预方法，据推测它可以增强夜间禁食/酮症的代谢益处。这项初步研究调查了每日 14 小时代谢禁食（14:10 TRE，晚餐后开始，12 小时时吃“禁食零食”，14 小时后吃早餐）与商业体重管理计划相结合对肥胖个体体重和空腹血糖（FBG）的有效性。我们还研究了低热量、高脂肪、低碳水化合物和低蛋白质“禁食零食”对血糖的影响。
这项 8 周、随机、对照、临床试验纳入了 2020 年 6 月至 10 月期间的男性和女性（BMI≥30kg/m）。研究程序是远程进行的。参与者被随机分为 14:10 或 12 小时 TRE（12:12，活性对照），并接受饮食（热量和宏量营养素组成受控）和运动计划的规定，其中包括每周定制咨询和支持。主要结局是 14:10 组从基线到体重的变化。
在 78 名随机参与者中，有 60 名（n=30/组）完成了 8 周。14:10 组体重从基线的 LS 平均变化为-8.5%（95%CI-9.6 至-7.4；P<0.001）和-7.1%（-8.3 至-5.8；P<0.001），12:12 组（组间差异-1.4%；-2.7 至-0.2；P<0.05）。在 14:10 组中，从基线到第 8 周的空腹血糖 LS 平均变化为-7.6mg/dl（95%CI-15.1 至-0.1；P<0.05），但在 12:12 组中没有变化（-3.1mg/dl，-10.0 至 3.7；P=NS）。两项干预措施都导致基线时空腹血糖升高（≥100mg/dl）的参与者的空腹血糖有更大的降低（均 P<0.05）。
在肥胖参与者中，完成 14:10 TRE 方案和商业减肥计划 8 周后，体重显著减轻，空腹血糖显著改善。
