使用羟丁酸钠治疗与睡眠相关的疼痛性勃起。
Sleep-related painful erections treated with sodium oxybate.
机构信息
Neurology Department, The Mayo Clinic in Arizona, Scottsdale, Arizona.
Urology Department, The Mayo Clinic in Arizona, Scottsdale, Arizona.
出版信息
J Clin Sleep Med. 2024 Jul 1;20(7):1209-1211. doi: 10.5664/jcsm.11120.
UNLABELLED
A 39-year-old male with a medical history significant for migraine, psoriatic arthritis, postural orthostatic tachycardia syndrome, vitamin D deficiency, and hypoglycemia presented with a 2-year history of sleep-related painful erections. Because the reported prevalence is low, there is limited understanding of the possible etiologies of the disorder and few published clinical data on treatment algorithms. Thus, he had tried multiple therapies. Baclofen was effective but not tolerated. Pelvic physiotherapy and tadalafil were ineffective. Imipramine, clonazepam, vitamin B, iron, and selenium provided minimal benefit. Opiates were initially effective but lost efficacy after 2-3 weeks. Finally, he was started on sodium oxybate after fully counseling the patient on the potential side effects of the treatment and consenting the patient for off-label use. This has effectively treated his sleep-related painful erections. Sodium oxybate is a novel therapy for and a possible new treatment for this rare and challenging disorder that merits further study.
CITATION
Chaudhary HS, Zeidman E, Punjani N, Tashman Y. Sleep-related painful erections treated with sodium oxybate. . 2024;20(7):1209-1211.
未注明
一名 39 岁男性，既往有偏头痛、银屑病关节炎、体位性心动过速综合征、维生素 D 缺乏和低血糖病史，现因睡眠相关疼痛性勃起病史 2 年来就诊。由于报道的患病率较低，对该疾病的可能病因了解有限，且关于治疗方案的临床数据也很少。因此，他尝试了多种治疗方法。巴氯芬有效但不能耐受。骨盆物理治疗和他达拉非无效。阿米替林、氯硝西泮、维生素 B、铁和硒仅提供了轻微的益处。阿片类药物最初有效，但在 2-3 周后失去了疗效。最终，在对患者进行充分的治疗副作用告知并获得患者同意进行超适应证使用后，开始使用羟丁酸钠。这有效地治疗了他的睡眠相关疼痛性勃起。羟丁酸钠是一种治疗这种罕见且具有挑战性疾病的新疗法，值得进一步研究。
参考文献
Chaudhary HS, Zeidman E, Punjani N, Tashman Y. Sleep-related painful erections treated with sodium oxybate.. 2024;20(7):1209-1211.
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