Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.
School of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China.
ACS Nano. 2024 Mar 19;18(11):8360-8382. doi: 10.1021/acsnano.3c12950. Epub 2024 Mar 8.
Supramolecular hydrogels emerge as a promising paradigm for sutureless wound management. However, their translation is still challenged by the insufficient mechanical robustness in the context of complex wounds in dynamic tissues. Herein, we report a tissue-adhesive supramolecular hydrogel membrane based on biocompatible precursors for dressing wounds in highly dynamic tissues, featuring robust mechanical resilience through programmable strain-adaptive entanglement among microdomains. Specifically, the hydrogels are synthesized by incorporating a long-chain polyurethane segment into a Schiff base-ligated short-chain oxidized cellulose/quaternized chitosan network via acylhydrazone bonding, which readily establishes interpenetrating entangled microdomains in dynamic cross-linked hydrogel matrices to enhance their tear and fatigue resistance against extreme mechanical stresses. After being placed onto dynamic tissues, the hydrogel dressing could efficiently absorb blood to achieve rapid hemostasis. Moreover, metal ions released from ruptured erythrocytes could be scavenged by the Schiff base linkers to form additional ionic bonds, which would trigger the cross-linking of the short-chain components and establish abundant crystalline microdomains, eventually leading to the in situ stiffening of the hydrogels to endure heavy mechanical loads. Benefiting from its hemostatic capacity and strain adaptable mechanical performance, this hydrogel wound dressing shows promise for the clinical management of various traumatic wounds.
超分子水凝胶作为一种有前途的无缝线伤口管理范例而出现。然而，在动态组织中的复杂伤口的背景下，它们的转化仍然受到机械强度不足的挑战。在此，我们报告了一种基于生物相容性前体的组织粘附性超分子水凝胶膜，用于在高度动态组织中处理伤口，其通过微域之间可编程的应变适应性缠结实现了强大的机械弹性恢复能力。具体而言，通过酰腙键将长链聚氨酯段掺入席夫碱连接的短链氧化纤维素/季铵化壳聚糖网络中，合成了水凝胶，这在动态交联水凝胶基质中容易建立互穿缠结的微域，从而增强了其抗撕裂和抗疲劳能力，以抵抗极端机械应力。水凝胶敷料放置在动态组织上后，可以有效地吸收血液以实现快速止血。此外，破裂的红细胞释放的金属离子可以被席夫碱配体捕获，形成额外的离子键，这将触发短链成分的交联并建立丰富的结晶微域，最终导致水凝胶的原位硬化以承受重机械负载。得益于其止血能力和应变适应性机械性能，这种水凝胶伤口敷料有望用于各种创伤性伤口的临床管理。
