Institute of Pharmacognosy, University of Szeged, Szeged, Hungary.
Institute of Clinical Pharmacy, University of Szeged, Szeged, Hungary.
Planta Med. 2024 Aug;90(9):736-740. doi: 10.1055/a-2283-8147. Epub 2024 Mar 8.
Ginger has traditionally been used to treat and prevent nausea and vomiting; however, the results of clinical trials are ambiguous. The efficacy of ginger is attributed to gingerols and their metabolites, shogaols. Since these compounds have different pharmacological profiles, the clinical efficacy of ginger products is largely dependent on their chemical composition. The goal of our study was to examine the stability of ginger, determining the 6-gingerol contents in order to assess the effects of different storage conditions. We have performed a 6-month stability test with dry ginger rhizome samples stored in a constant climate chamber in three different storage containers (uncovered glass container, glass container sealed with rubber stopper, and plastic container). The 6-gingerol contents were measured by HPLC method. The concentration of 6-gingerol decreased in all samples. In the sealed glass container, the decrease in 6-gingerol content was significantly lower than in the unsealed glass container and in the plastic container. These results demonstrate that storage conditions have a significant impact on the quality of ginger, which may also affect efficacy.
生姜传统上被用于治疗和预防恶心和呕吐;然而,临床试验的结果并不明确。生姜的疗效归因于姜辣素及其代谢物,如姜烯酚。由于这些化合物具有不同的药理特性,生姜产品的临床疗效在很大程度上取决于其化学成分。我们的研究目的是检查生姜的稳定性,确定 6-姜辣素的含量,以评估不同储存条件的影响。我们对三种不同储存容器(无盖玻璃容器、用橡胶塞密封的玻璃容器和塑料容器)中储存的干生姜根茎样本进行了为期 6 个月的稳定性测试。通过高效液相色谱法测量 6-姜辣素的含量。所有样本中的 6-姜辣素含量都有所下降。在密封的玻璃容器中,6-姜辣素含量的下降明显低于无盖玻璃容器和塑料容器。这些结果表明,储存条件对生姜的质量有重大影响,这也可能影响疗效。