Jin Hui, Lin Ziyuan, Pang Tianyi, Wu Jingwen, Zhao Cheng, Zhang Ying, Lei Yu, Li Qilin, Yao Xu, Zhao Ming, Lu Qianjin
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China; Research Unit of Key Technologies of Immune-related Skin Diseases Diagnosis and Treatment, Chinese Academy of Medical Sciences Institute of Dermatology, Nanjing, China.
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Sci Total Environ. 2024 May 15;925:171492. doi: 10.1016/j.scitotenv.2024.171492. Epub 2024 Mar 6.
Polycyclic aromatic hydrocarbons (PAHs) are hydrocarbons characterized by the presence of multiple benzene rings. They are ubiquitously found in the natural environment, especially in environmental pollutants, including atmospheric particulate matter, cigarette smoke, barbecue smoke, among others. PAHs can influence human health through several mechanisms, including the aryl hydrocarbon receptor (AhR) pathway, oxidative stress pathway, and epigenetic pathway. In recent years, the impact of PAHs on inflammatory skin diseases has garnered significant attention, yet many of their underlying mechanisms remain poorly understood. We conducted a comprehensive review of articles focusing on the link between PAHs and several inflammatory skin diseases, including psoriasis, atopic dermatitis, lupus erythematosus, and acne. This review summarizes the effects and mechanisms of PAHs in these diseases and discusses the prospects and potential therapeutic implications of PAHs for inflammatory skin diseases.
多环芳烃（PAHs）是一类以含有多个苯环为特征的碳氢化合物。它们广泛存在于自然环境中，尤其是在环境污染物中，包括大气颗粒物、香烟烟雾、烧烤烟雾等。多环芳烃可通过多种机制影响人类健康，包括芳烃受体（AhR）途径、氧化应激途径和表观遗传途径。近年来，多环芳烃对炎症性皮肤病的影响已引起广泛关注，但其许多潜在机制仍知之甚少。我们对聚焦于多环芳烃与几种炎症性皮肤病（包括银屑病、特应性皮炎、红斑狼疮和痤疮）之间联系的文章进行了全面综述。本综述总结了多环芳烃在这些疾病中的作用和机制，并讨论了多环芳烃对炎症性皮肤病的研究前景和潜在治疗意义。
