The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Jiangxi Medical College, Nanchang University, Nanchang, China.
HuanKui Academy, Jiangxi Medical College, Nanchang University, Nanchang, China.
Carcinogenesis. 2024 Jun 10;45(6):363-377. doi: 10.1093/carcin/bgae021.
Long non-coding RNAs (lncRNAs) have been established as pivotal players in various cellular processes, encompassing the regulation of transcription, translation and post-translational modulation of proteins, thereby influencing cellular functions. Notably, lncRNAs exert a regulatory influence on diverse biological processes, particularly in the context of tumor development. Tumor-associated macrophages (TAMs) exhibit the M2 phenotype, exerting significant impact on crucial processes such as tumor initiation, angiogenesis, metastasis and immune evasion. Elevated infiltration of TAMs into the tumor microenvironment (TME) is closely associated with a poor prognosis in various cancers. LncRNAs within TAMs play a direct role in regulating cellular processes. Functioning as integral components of tumor-derived exosomes, lncRNAs prompt the M2-like polarization of macrophages. Concurrently, reports indicate that lncRNAs in tumor cells contribute to the expression and release of molecules that modulate TAMs within the TME. These actions of lncRNAs induce the recruitment, infiltration and M2 polarization of TAMs, thereby providing critical support for tumor development. In this review, we survey recent studies elucidating the impact of lncRNAs on macrophage recruitment, polarization and function across different types of cancers.
长非编码 RNA（lncRNAs）已被确定为各种细胞过程中的关键参与者，包括转录、翻译和蛋白质的翻译后调节，从而影响细胞功能。值得注意的是，lncRNAs 对多种生物学过程发挥着调节作用，特别是在肿瘤发展方面。肿瘤相关巨噬细胞（TAMs）表现出 M2 表型，对肿瘤起始、血管生成、转移和免疫逃逸等关键过程产生重大影响。TAMs 浸润肿瘤微环境（TME）的增加与各种癌症的不良预后密切相关。TAMs 中的 lncRNAs 直接参与调节细胞过程。作为肿瘤衍生外泌体的组成部分，lncRNAs 促使巨噬细胞发生 M2 样极化。同时，有报道称肿瘤细胞中的 lncRNAs 有助于调节 TME 中 TAMs 的表达和释放分子。lncRNAs 的这些作用诱导 TAMs 的募集、浸润和 M2 极化，从而为肿瘤发展提供关键支持。在这篇综述中，我们调查了最近的研究，这些研究阐明了 lncRNAs 对不同类型癌症中巨噬细胞募集、极化和功能的影响。
