Instituto de Biodiversidade e Sustentabilidade-NUPEM, Universidade Federal do Rio de Janeiro (UFRJ), Av. São José do Barreto, 764, Macaé, Rio de Janeiro, CEP: 27920-560, Brazil.
Probiotics Antimicrob Proteins. 2024 Oct;16(5):1608-1622. doi: 10.1007/s12602-024-10241-3. Epub 2024 Mar 9.
Spiders produce webs, which are still a largely unexplored source of antibacterial compounds, although the reports of its application in the medical field. Therefore, this study aims to present an integrative review of the antibacterial activity of spider webs. The research was conducted using Google Scholar, Scielo, Web of Science, PubMed, ScienceDirect, Medline EBSCO, LILACS, and Embase. The inclusion criteria were original articles written in English that studied the antibiotic properties of the web or isolated compounds tested. The studies were compared according to the spider species studied, the type of web, treatment of the sample, type of antimicrobial test, and the results obtained. Nine hundred and seventy-three publications were found, and after applying the inclusion and exclusion criteria, sixteen articles were selected. Bacterial inhibition was found in seven studies against various species of bacteria such as Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Salmonella Typhi, Bacillus megaterium, Listeria monocytogenes, Acinetobacter baumannii, Streptococcus pneumoniae, Pasteurella multocida, and Bacillus subtilis. Additionally, there was no apparent relationship between the proximity of the spider species evaluated in the studies and the presence or absence of activity. Methodological problems detected may affected the reproducibility and reliability of the results in some studies, such as the lack of description of the web or microorganism strain, as well as the absence of adequate controls and treatments to sterilize the sample. Spider webs can be a valuable source of antibiotics; however, more studies are needed to confirm the real activity of the web or components involved.
蜘蛛会织网，尽管已经有一些关于其在医学领域应用的报告，但蜘蛛网仍然是一个抗菌化合物的未被充分探索的来源。因此，本研究旨在对蜘蛛网的抗菌活性进行综合综述。研究使用了 Google Scholar、Scielo、Web of Science、PubMed、ScienceDirect、Medline EBSCO、LILACS 和 Embase 进行。纳入标准为英文原创文章，研究蜘蛛webs 的抗生素特性或测试的分离化合物。根据研究的蜘蛛种类、webs 类型、样品处理、抗菌试验类型和获得的结果对研究进行比较。共发现 973 篇出版物，在应用纳入和排除标准后，选择了 16 篇文章。有 7 项研究发现了针对各种细菌的抑菌作用，如大肠杆菌、肺炎克雷伯菌、金黄色葡萄球菌、伤寒沙门氏菌、巨大芽孢杆菌、单核细胞增生李斯特菌、鲍曼不动杆菌、肺炎链球菌、多杀巴斯德氏菌和枯草芽孢杆菌。此外，在所评估的蜘蛛种类与活性的有无之间没有明显的关系。一些研究中检测到的方法学问题可能会影响结果的可重复性和可靠性，例如缺乏对 webs 或微生物菌株的描述，以及缺乏足够的对照和处理来对样品进行灭菌。蜘蛛 webs 可能是抗生素的有价值来源；然而，需要更多的研究来确认 webs 或相关成分的实际活性。
