Case Western Reserve University School of Medicine, Cleveland, Ohio.
Case Western Reserve University School of Medicine, Cleveland, Ohio; Center for Pediatric Ophthalmology and Adult Strabismus, Rainbow Babies and Children's Hospital, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
J AAPOS. 2024 Apr;28(2):103870. doi: 10.1016/j.jaapos.2024.103870. Epub 2024 Mar 8.
To examine the prevalence of and factors associated with racial and ethnic reporting and trends in such reporting and to assess whether categories of race and ethnicity have been under- or over-represented in pediatric ophthalmology randomized control trials (RCTs) in the United States.
We systematically searched the literature on pediatric ophthalmology RCTs in high-impact factor ophthalmology journals published between 2000 and 2022. Logistic regression was used to assess parameters linked to race/ethnicity reporting; linear regression, to gauge the relationship between publication year and race/ethnicity reporting. The racial and ethnic composition of RCTs was contrasted with 2010 US census data by calculating percentage difference.
Of 170 eligible articles, 89 (52.4%) included race/ethnicity data. Multivariable analysis showed that academic (OR = 12.19; 95% CI, 3.34-44.44) and government (OR = 3.91; 95% CI, 1.20-12.72) funding was linked to data reporting. During the study period, publication year and race/ethnicity reporting had a nonstatistically significant 1.0% annual increase (r = 0.29, P = 0.18). White participants were over-represented, with a percentage difference of 16.7% (95% CI, 11.8%-21.7%), whereas Hispanic individuals were under-represented, with a percentage difference of -7.6% (95% CI, -11.2% to -4.1%) compared to the 2010 US census data.
Our results indicate a gradual rise in reported race and/or ethnicity in published pediatric ophthalmology RCTs, though not statistically significant, both in the United States and globally. Notably, under-representation of Hispanic, over-representation of White, and proportional representation of Black and Asian individuals were observed in US-based studies.
调查美国儿科眼科学随机对照试验（RCT）中种族和民族报告的流行情况和相关因素，以及这些报告的趋势，并评估种族和民族类别是否在儿科眼科学 RCT 中被低估或高估。
我们系统地检索了 2000 年至 2022 年在高影响力因素眼科学期刊上发表的儿科眼科学 RCT 文献。使用逻辑回归评估与种族/民族报告相关的参数；线性回归评估出版年份与种族/民族报告之间的关系。通过计算百分比差异，将 RCT 的种族和民族构成与 2010 年美国人口普查数据进行对比。
在 170 篇符合条件的文章中，有 89 篇（52.4%）包含种族/民族数据。多变量分析表明，学术（OR=12.19；95%CI，3.34-44.44）和政府（OR=3.91；95%CI，1.20-12.72）资助与数据报告有关。在研究期间，出版年份和种族/民族报告每年增加 1.0%，但无统计学意义（r=0.29，P=0.18）。白人参与者的比例过高，差异百分比为 16.7%（95%CI，11.8%-21.7%），而西班牙裔个体的比例过低，差异百分比为-7.6%（95%CI，-11.2%至-4.1%），与 2010 年美国人口普查数据相比。
我们的研究结果表明，美国和全球发表的儿科眼科学 RCT 中报告的种族和/或民族数量逐渐增加，尽管没有统计学意义。值得注意的是，在美国进行的研究中观察到西班牙裔人群代表性不足，白人人群代表性过高，黑人和亚洲人群代表性适中。
