Glymphatic system, sleep, and Parkinson's disease: interconnections, research opportunities, and potential for disease modification.
作者信息
Nepozitek Jiri, Dusek Petr, Sonka Karel
机构信息
Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, 12000 Prague, Czech Republic.
Department of Radiology, First Faculty of Medicine, Charles University and General University Hospital, 12000 Prague, Czech Republic.
出版信息
Sleep. 2025 Jan 13;48(1). doi: 10.1093/sleep/zsae251.
Abstract
摘要
相似文献
1
Glymphatic system, sleep, and Parkinson's disease: interconnections, research opportunities, and potential for disease modification.类淋巴系统、睡眠与帕金森病：相互联系、研究机遇及疾病改善潜力
Sleep. 2025 Jan 13;48(1). doi: 10.1093/sleep/zsae251.
2
Targeting the glymphatic system to promote α-synuclein clearance: a novel therapeutic strategy for Parkinson's disease.靶向类淋巴系统促进α-突触核蛋白清除：帕金森病的一种新治疗策略。
Neural Regen Res. 2025 Jan 13;21(1):233-47. doi: 10.4103/NRR.NRR-D-24-00764.
3
Interplay between the glymphatic system and neurotoxic proteins in Parkinson's disease and related disorders: current knowledge and future directions.帕金森病及相关疾病中淋巴系统与神经毒性蛋白之间的相互作用：当前认知与未来方向。
Neural Regen Res. 2024 Sep 1;19(9):1973-1980. doi: 10.4103/1673-5374.390970. Epub 2023 Dec 15.
4
Glymphatic System Dysfunction and Sleep Disturbance May Contribute to the Pathogenesis and Progression of Parkinson's Disease.糖脂代谢系统功能障碍与睡眠障碍可能导致帕金森病的发病与进展。
Int J Mol Sci. 2022 Oct 26;23(21):12928. doi: 10.3390/ijms232112928.
5
Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson's disease.建立帕金森病神经病理学相关性和糖酵解系统功能的框架。
Neurosci Biobehav Rev. 2019 Aug;103:305-315. doi: 10.1016/j.neubiorev.2019.05.016. Epub 2019 May 24.
6
The Impact of Sleep Disorders on Glymphatic Function in Parkinson's Disease Using Diffusion Tensor MRI.使用扩散张量磁共振成像研究睡眠障碍对帕金森病中淋巴系统功能的影响
Acad Radiol. 2025 Apr;32(4):2209-2219. doi: 10.1016/j.acra.2024.11.030. Epub 2024 Dec 2.
7
Relationship of Glymphatic Function with Cognitive Impairment, Sleep Disorders, Anxiety and Depression in Patients with Parkinson's Disease.帕金森病患者中类淋巴系统功能与认知障碍、睡眠障碍、焦虑和抑郁的关系
Neuropsychiatr Dis Treat. 2024 Sep 25;20:1809-1821. doi: 10.2147/NDT.S480183. eCollection 2024.
8
Glymphatic dysfunction exacerbates cognitive decline by triggering cortical degeneration in Parkinson's disease: evidence from diffusion-tensor MRI.类淋巴系统功能障碍通过引发帕金森病中的皮质变性加剧认知衰退：来自扩散张量磁共振成像的证据
Brain Commun. 2025 Feb 20;7(1):fcaf029. doi: 10.1093/braincomms/fcaf029. eCollection 2025.
9
The Role of Glymphatic System in Alzheimer's and Parkinson's Disease Pathogenesis.类淋巴系统在阿尔茨海默病和帕金森病发病机制中的作用。
Biomedicines. 2022 Sep 13;10(9):2261. doi: 10.3390/biomedicines10092261.
10
The glymphatic system and Amyotrophic lateral sclerosis.糖胺聚糖系统与肌萎缩性侧索硬化症。
Prog Neurobiol. 2024 Mar;234:102571. doi: 10.1016/j.pneurobio.2024.102571. Epub 2024 Jan 22.
引用本文的文献
1
Obstructive sleep apnea as a possible mediator for the association between glymphatic function and body mass index in Parkinson's disease.阻塞性睡眠呼吸暂停作为帕金森病中淋巴系统功能与体重指数之间关联的潜在中介因素。
Quant Imaging Med Surg. 2025 Aug 1;15(8):7674-7675. doi: 10.21037/qims-2025-1124. Epub 2025 Jul 24.
2
Glymphatic dysfunction evidenced by DTI-ALPS is related to obstructive sleep apnea intensity in newly diagnosed Parkinson's disease.由扩散张量成像-动脉自旋标记灌注成像（DTI-ALPS）所证实的脑淋巴系统功能障碍与新诊断帕金森病的阻塞性睡眠呼吸暂停严重程度相关。
NPJ Parkinsons Dis. 2025 Jun 11;11(1):160. doi: 10.1038/s41531-025-01018-8.
3
Exploring glymphatic system alterations in iRBD and Parkinson's disease using automated DTI-ALPS analysis.使用自动扩散张量成像-阿尔茨海默病谱系评分（DTI-ALPS）分析探索快速眼动期行为障碍（iRBD）和帕金森病中的脑淋巴系统改变。
NPJ Parkinsons Dis. 2025 Apr 15;11(1):76. doi: 10.1038/s41531-025-00921-4.
本文引用的文献
1
T2 MRI visible perivascular spaces in Parkinson's disease: clinical significance and association with polysomnography measured sleep.帕金森病中T2加权磁共振成像可见的血管周围间隙：临床意义及与多导睡眠图测量睡眠的相关性
Sleep. 2025 Jan 13;48(1). doi: 10.1093/sleep/zsae233.
2
Impaired glymphatic clearance in multiple system atrophy: A diffusion spectrum imaging study.多系统萎缩中糖质淋系统清除功能受损：一项弥散谱成像研究。
Parkinsonism Relat Disord. 2024 Jun;123:106950. doi: 10.1016/j.parkreldis.2024.106950. Epub 2024 Mar 29.
3
The glymphatic system in migraine and other headaches.偏头痛及其他头痛中的类淋巴系统。
J Headache Pain. 2024 Mar 11;25(1):34. doi: 10.1186/s10194-024-01741-2.
4
Old problems, new solutions: harnessing technology and innovation in Parkinson's disease-evidence and experiences from Thailand.旧问题，新解决方案：利用技术和创新治疗帕金森病——来自泰国的证据和经验。
J Neural Transm (Vienna). 2024 Jun;131(6):721-738. doi: 10.1007/s00702-023-02727-1. Epub 2024 Jan 8.
5
DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke.弥散张量成像-阿尔伯塔脑白质病变评分：亚急性缺血性脑卒中患者运动功能障碍的一种磁共振生物标志物。
Front Neurosci. 2023 Mar 31;17:1132393. doi: 10.3389/fnins.2023.1132393. eCollection 2023.
6
Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport.雄性小鼠睡眠周期依赖性血管动力学及其对血管周围脑脊髓液流动和溶质转运的预测影响。
Nat Commun. 2023 Feb 20;14(1):953. doi: 10.1038/s41467-023-36643-5.
7
Astrocytes as a Therapeutic Target in Alzheimer's Disease-Comprehensive Review and Recent Developments.星形胶质细胞作为阿尔茨海默病的治疗靶点：全面综述和最新进展。
Int J Mol Sci. 2022 Nov 7;23(21):13630. doi: 10.3390/ijms232113630.
8
Glymphatic System Dysfunction and Sleep Disturbance May Contribute to the Pathogenesis and Progression of Parkinson's Disease.糖脂代谢系统功能障碍与睡眠障碍可能导致帕金森病的发病与进展。
Int J Mol Sci. 2022 Oct 26;23(21):12928. doi: 10.3390/ijms232112928.
9
The Role of Glymphatic System in Alzheimer's and Parkinson's Disease Pathogenesis.类淋巴系统在阿尔茨海默病和帕金森病发病机制中的作用。
Biomedicines. 2022 Sep 13;10(9):2261. doi: 10.3390/biomedicines10092261.
10
Small and Large Magnetic Resonance Imaging-Visible Perivascular Spaces in the Basal Ganglia of Parkinson's Disease Patients.帕金森病患者基底节区小和大磁共振成像可见血管周围间隙。
Mov Disord. 2022 Jun;37(6):1304-1309. doi: 10.1002/mds.29010. Epub 2022 Apr 11.
Zotero 插件