Yao Kaiwei, Iqbal Muhammad Asad, Moazzam Nida Fatima, Qian Wei
Department of Otorhinolaryngology-Head and Neck Surgery, The Affiliated People's Hospital of Jiangsu University, Zhenjiang First People's Hospital, Zhenjiang, Jiangsu, China.
School of Medicine, Jiangsu University, Zhenjiang, China.
Ear Nose Throat J. 2024 Mar 10:1455613241232796. doi: 10.1177/01455613241232796.
To study the factors associated with the prognosis of patients with sudden deafness to facilitate clinical treatment and improve efficacy. A total of 414 patients with sudden deafness treated in Zhenjiang First People's Hospital from January 2020 to December 2022 were chosen. Relevant data were gathered and the effectiveness of treatment was assessed by comparing hearing test results before and after hospital admission and divided into effective and ineffective groups, and the effectiveness of each factor was analyzed using univariate analysis, Spearman's correlation analysis, and multifactor logistic regression. The 2 groups had significant differences in age, presence of tinnitus, degree of hearing loss, and triglyceride levels. Spearman's rank correlation analysis showed a negative correlation between hearing threshold of at least 81 dB at 250 to 8000 Hz, the low-density lipoprotein (LDL), triglyceride levels, and the prognosis ( < 0, < .001). A positive correlation exists between high-density lipoprotein levels and prognosis ( > 0, < .001). Receiver operating characteristic curve showed LDL level, age, and time since disease onset appears to be highly predictive. Multivariable logistic regression analysis showed that age >47 years, LDL >2.93 mmol/L, and time to presentation >10 days after disease onset are at higher risk for poor prognosis. Factors that influence the prognosis of patients with sudden deafness include age, tinnitus symptoms, high LDL levels, and the type of hearing curve. Early intervention and targeted treatment should be given to high-risk patients to improve the outcome of sudden deafness in clinical practice.
研究突发性聋患者预后的相关因素，以促进临床治疗并提高疗效。选取2020年1月至2022年12月在镇江市第一人民医院治疗的414例突发性聋患者。收集相关数据，通过比较入院前后听力测试结果评估治疗效果，分为有效组和无效组，并采用单因素分析、Spearman相关性分析和多因素logistic回归分析各因素的有效性。两组在年龄、耳鸣情况、听力损失程度和甘油三酯水平方面存在显著差异。Spearman等级相关性分析显示，250至8000Hz至少81dB的听力阈值、低密度脂蛋白（LDL）、甘油三酯水平与预后呈负相关（<0，<.001）。高密度脂蛋白水平与预后呈正相关（>0，<.001）。受试者工作特征曲线显示LDL水平、年龄和发病时间似乎具有高度预测性。多变量logistic回归分析显示，年龄>47岁、LDL>2.93mmol/L以及发病后就诊时间>10天预后不良风险较高。影响突发性聋患者预后的因素包括年龄、耳鸣症状、LDL水平升高和听力曲线类型。临床实践中应对高危患者进行早期干预和针对性治疗，以改善突发性聋的治疗效果。
