Rashid Safia, Sado Abdulmaleek Idanesimhe, Afzal Muhammad Sohaib, Ahmed Amna, Almaalouli Bsher, Waheed Tallha, Abid Rabia, Majumder Koushik, Kumar Vikash, Tejwaney Usha, Kumar Sarwan
Dow University of Health Sciences.
Penwortham, St Mary's Medical Group, Penwortham, Preston, United Kingdom.
Ann Med Surg (Lond). 2023 Oct 18;86(3):1483-1489. doi: 10.1097/MS9.0000000000001419. eCollection 2024 Mar.
The connection between cardiovascular illnesses and the gut microbiota has drawn more and more attention in recent years. According to research, there are intricate relationships between dietary elements, gut bacteria, and their metabolites that affect cardiovascular health. In this study, the role of gut microbiota in cardiovascular disorders is examined, with an emphasis on the cardiac consequences brought on by changes in gut microbiota. This essay discusses the gut-heart axis in depth and in detail. It talks about clinical research looking at how soy consumption, probiotic supplements, and dietary changes affected gut microbiota and cardiovascular risk variables. Our goal is to clarify the possible pathways that connect gut microbiota to cardiovascular health and the implications for upcoming treatment approaches. The authors examine the composition, roles, and effects of the gut microbiota on cardiovascular health, including their contributions to hypertension, atherosclerosis, lipid metabolism, and heart failure. Endotoxemia, inflammation, immunological dysfunction, and host lipid metabolism are some of the potential processes investigated for how the gut microbiota affects cardiac outcomes. The research emphasizes the need for larger interventional studies and personalized medicine strategies to completely understand the complexity of the gut-heart axis and its implications for the management of cardiovascular disease. The development of novel treatment strategies and cutting-edge diagnostic technologies in cardiovascular medicine may be facilitated by a better understanding of this axis.
近年来,心血管疾病与肠道微生物群之间的联系越来越受到关注。根据研究,饮食元素、肠道细菌及其代谢产物之间存在着复杂的关系,这些关系会影响心血管健康。在这项研究中,我们探讨了肠道微生物群在心血管疾病中的作用,重点关注肠道微生物群变化所带来的心脏影响。本文深入且详细地讨论了肠-心轴。它讲述了关于大豆消费、益生菌补充剂和饮食变化如何影响肠道微生物群以及心血管风险变量的临床研究。我们的目标是阐明连接肠道微生物群与心血管健康的可能途径以及对未来治疗方法的影响。作者研究了肠道微生物群的组成、作用及其对心血管健康的影响,包括它们在高血压、动脉粥样硬化、脂质代谢和心力衰竭中的作用。内毒素血症、炎症、免疫功能障碍和宿主脂质代谢是研究肠道微生物群如何影响心脏结果的一些潜在机制。该研究强调需要进行更大规模的干预性研究和个性化医疗策略,以全面了解肠-心轴的复杂性及其对心血管疾病管理的影响。更好地理解这一轴可能会促进心血管医学中新型治疗策略和前沿诊断技术的发展。