Lin Li, Xiang Shaowei, Chen Yuan, Liu Yan, Shen Dingwen, Yu Xiaoping, Wu Zhe, Sun Yanling, Chen Kequan, Luo Jia, Wei Guilai, Wang Zhiguo, Ning Zhifeng
Department of Biochemistry, Basic Medicine School, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China.
Department of Neurosurgery, Enshi State Central Hospital, Enshi, Hubei 445000, P.R. China.
Exp Ther Med. 2024 Sep 11;28(5):427. doi: 10.3892/etm.2024.12716. eCollection 2024 Nov.
The gut microbiota refers to the diverse bacterial community residing in the gastrointestinal tract. Recent data indicate a strong correlation between alterations in the gut microbiota composition and the onset of various diseases, notably cardiovascular disorders. Evidence suggests the gut-cardiovascular axis signaling molecules released by the gut microbiota play a pivotal role in regulation. This review systematically delineates the association between dysbiosis of the gut microbiota and prevalent cardiovascular diseases, including atherosclerosis, hypertension, myocardial infarction and heart failure. Furthermore, it provides an overview of the putative pathogenic mechanisms by which dysbiosis in the gut microbiota contributes to the progression of cardiovascular ailments. The potential modulation of gut microbiota as a preventive strategy against cardiovascular diseases through dietary interventions, antibiotic therapies and probiotic supplementation is also explored and discussed within the present study.
肠道微生物群是指存在于胃肠道中的多种细菌群落。最近的数据表明，肠道微生物群组成的改变与各种疾病的发生之间存在密切关联，尤其是心血管疾病。有证据表明，肠道微生物群释放的肠道-心血管轴信号分子在调节中起关键作用。本综述系统地阐述了肠道微生物群失调与常见心血管疾病（包括动脉粥样硬化、高血压、心肌梗死和心力衰竭）之间的关联。此外，还概述了肠道微生物群失调导致心血管疾病进展的潜在致病机制。本研究还探讨并讨论了通过饮食干预、抗生素治疗和补充益生菌等方式对肠道微生物群进行潜在调节，作为预防心血管疾病的策略。
