Barkovich Krister J, Zhao Zhongchao, Steinmetz Nicole F
Department of Radiology, University of California, San Diego, San Diego, CA.
Department of NanoEngineering, University of California, San Diego, San Diego, CA.
Small Sci. 2023 Aug;3(8). doi: 10.1002/smsc.202300067. Epub 2023 Jun 27.
Nanomedicine provides a promising platform for the molecular treatment of disease. An ongoing challenge in nanomedicine is the targeted delivery of intravenously administered nanoparticles to particular tissues, which is of special interest in cancer. In this study, we show that the conjugation of iRGD peptides, which specifically target tumor neovasculature, to the surface of Physalis mottle virus (PhMV)-like nanoparticles leads to rapid cellular uptake and tumor homing . We then show that iRGD-targeted PhMV loaded with the chemotherapeutic doxorubicin shows increased potency in a murine flank xenograft model of cancer. Our results validate that PhMV-like nanoparticles can be targeted to tumors through iRGD-peptide conjugation and suggest that iRGD-PhMV provides a promising platform for the targeted delivery of molecular cargo to tumors.
纳米医学为疾病的分子治疗提供了一个有前景的平台。纳米医学中一个持续存在的挑战是将静脉注射的纳米颗粒靶向递送至特定组织，这在癌症治疗中尤为重要。在本研究中，我们表明，将特异性靶向肿瘤新生血管的iRGD肽与酸浆斑驳病毒（PhMV）样纳米颗粒表面偶联，可导致细胞快速摄取和肿瘤归巢。然后我们表明，负载化疗药物阿霉素的iRGD靶向PhMV在小鼠侧腹异种移植癌模型中显示出增强的效力。我们的结果证实，PhMV样纳米颗粒可通过iRGD肽偶联靶向肿瘤，并表明iRGD-PhMV为将分子货物靶向递送至肿瘤提供了一个有前景的平台。
