Nakamura Hiroki, Yamamoto Akira, Fukunaga Takeshi, Watanabe Hiroyuki, Ito Kosuke, Higaki Atushi, Kanki Akihiko, Fukukura Yoshihiko, Tamada Tsutomu
Departments of Radiology, Kawasaki Medical School, 577 , Matsushima, Kurashiki City, Okayama, Japan.
CVIR Endovasc. 2024 Mar 11;7(1):27. doi: 10.1186/s42155-024-00441-x.
Imipenem/cilastatin (IPM/CS) has long been administered intravenously as a carbapenem antibiotic. However, since this agent is poorly soluble in liquid, occasional reports have described its use as a short-acting, temporary embolic agent. The purpose of this study was to elucidate the characteristics of IPM/CS particles, which are thought to have pain-relieving effects against osteoarthritis-related pain, as an embolic agent.
Three aspects of IPM/CS as an embolic agent were evaluated in vitro: particle size; particle shape; and change in particle size over time. For particle size, the long diameter was measured.
Mean particle size (n=244) was 29.2±12.0 µm (range, 1-60 µm). Shape (n=109) was round in 18.35%, elliptical in 11.93%, and polygonal in 69.72%, showing that most particles were polygonal. In observations of changes in particle size over time (n=9), particles had decreased to 75% of their original size at 82±10.7 min, 50% at 89.3±9.14 min, 25% at 91.3±8.74 min, complete dissolved at 91.8±9.02 min. A rapid shrinkage in diameter was seen in the final period.
IPM/CS particles are ultrafine and the majority display a polygonal shape. This substance shows ultra-short embolic activity. This study revealed the characteristics of a substance that demonstrates an embolic effect not found in existing embolic materials.
亚胺培南/西司他丁（IPM/CS）长期以来一直作为碳青霉烯类抗生素进行静脉给药。然而，由于该药物在液体中溶解度较差，偶尔有报道称其可作为短效临时栓塞剂使用。本研究的目的是阐明IPM/CS颗粒作为栓塞剂对骨关节炎相关疼痛具有止痛作用的特性。
在体外评估IPM/CS作为栓塞剂的三个方面：粒径、颗粒形状以及粒径随时间的变化。对于粒径，测量其长径。
平均粒径（n = 244）为29.2±12.0 µm（范围为1 - 60 µm）。颗粒形状（n = 109）：圆形占18.35%，椭圆形占11.93%，多边形占69.72%，表明大多数颗粒为多边形。在观察粒径随时间的变化（n = 9）时，颗粒在82±10.7分钟时减小至原始大小的75%，在89.3±9.14分钟时减小至50%，在91.3±8.74分钟时减小至25%，在91.8±9.02分钟时完全溶解。在最后阶段观察到直径迅速缩小。
IPM/CS颗粒极细，大多数呈多边形。该物质显示出超短的栓塞活性。本研究揭示了一种具有栓塞作用的物质的特性，这种特性在现有的栓塞材料中未发现。
