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淀粉基纳米材料在生物医药中应用的研究进展综述:精准药物输送和癌症治疗。

A review on advancements in the application of starch-based nanomaterials in biomedicine: Precision drug delivery and cancer therapy.

机构信息

Qinba State Key Laboratory of Biological Resources and Ecological Environment, 2011 QinLing-Bashan Mountains Bioresources Comprehensive Development C. I. C, Shaanxi Province Key Laboratory of Bio-Resources, College of Bioscience and Bioengineering, Shaanxi University of Technology, Hanzhong 723001, China.

Department of anaesthesia, Xi'an Central Hospital, No. 161, West 5th Road, Xincheng District, Xi'an 710003, China.

出版信息

Int J Biol Macromol. 2024 Apr;265(Pt 1):130746. doi: 10.1016/j.ijbiomac.2024.130746. Epub 2024 Mar 10.

Abstract

The burgeoning field of starch-based nanomaterials in biomedical applications has perceived notable progressions, with a particular emphasis on their pivotal role in precision drug delivery and the inhibition of tumor growth. The complicated challenges in current biomedical research require innovative approaches for improved therapeutic outcomes, prompting an exploration into the possible of starch-based nanomaterials. The conceptualization of this review emerged from recognizing the need for a comprehensive examination of the structural attributes, versatile properties, and mechanisms underlying the efficiency of starch-based nanomaterials in inhibiting tumor growth and enabling targeted drug delivery. This review delineates the substantial growth in utilizing starch-based nanomaterials, elucidating their small size, high surface-volume ratio, and biocompatibility, predominantly emphasizing their possible to actively recognize cancer cells, deliver anticancer drugs, and combat tumors efficiently. The investigation of these nanomaterials encompasses to improving biocompatibility and targeting specific tissues, thereby contributing to the evolving landscape of precision medicine. The review accomplishes by highlighting the auspicious strategies and modern developments in the field, envisioning a future where starch-based nanomaterials play a transformative role in molecular nanomaterials, evolving biomedical sciences. The translation of these advancements into clinical applications holds the potential to revolutionize targeted drug delivery and expand therapeutic outcomes in the realm of precision medicine.

摘要

在生物医药应用中,淀粉基纳米材料这一新兴领域取得了显著进展,尤其侧重于其在精准药物输送和抑制肿瘤生长方面的关键作用。当前生物医药研究中的复杂挑战需要创新方法来改善治疗效果,这促使人们探索淀粉基纳米材料的可能性。本文的构思源于认识到需要全面考察淀粉基纳米材料的结构属性、多功能特性以及在抑制肿瘤生长和实现靶向药物输送方面的效率机制。本文详细阐述了利用淀粉基纳米材料的显著增长,阐明了其小尺寸、高表面积-体积比和生物相容性,重点强调了其主动识别癌细胞、输送抗癌药物和有效对抗肿瘤的潜力。对这些纳米材料的研究包括提高生物相容性和靶向特定组织,从而为精准医学的不断发展做出贡献。本文通过强调该领域的有前途的策略和现代发展,展望了淀粉基纳米材料在分子纳米材料和演进中的生物医学科学中发挥变革性作用的未来。将这些进展转化为临床应用有潜力彻底改变靶向药物输送并扩大精准医学领域的治疗效果。

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