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七氟醚和瑞芬太尼麻醉期间1型Brugada综合征患者ST段抬高持续缓解:一例报告

Sustained mitigation of ST-segment elevation in a patient with Brugada syndrome type 1 during sevoflurane and remifentanil anesthesia: a case report.

作者信息

Saito Kurumi, Yoshida Hitoshi, Hirota Kazuyoshi

机构信息

Department of Anesthesiology, Hirosaki General Medical Center, 1 Tomino-Cho, Hirosaki, 036-8174, Japan.

Department of Anesthesiology, Hirosaki University Graduate School of Medicine, 5 Zaifu-Cho, Hirosaki, 036-8562, Japan.

出版信息

JA Clin Rep. 2024 Mar 12;10(1):18. doi: 10.1186/s40981-024-00702-7.

DOI:10.1186/s40981-024-00702-7
PMID:38467908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10928048/
Abstract

BACKGROUND

During general anesthesia, patients with Brugada syndrome are at risk of malignant arrhythmias following worsened ST-segment elevation, potentially leading to sudden cardiac death. The protocol for safe anesthetic management of patients with Brugada syndrome has not yet been established.

CASE PRESENTATION

A 63-year-old man, diagnosed with a spontaneous Brugada type 1 pattern, was scheduled for a pleural biopsy using video-assisted thoracoscopic surgery under general anesthesia. We planned general anesthesia using volatile induction and maintenance anesthesia with sevoflurane and remifentanil. We monitored ST-segment morphology and observed sustained mitigation of ST-segment elevation throughout general anesthesia.

CONCLUSION

The present case may indicate that safe anesthetic management of patients with Brugada syndrome depends on whether the anesthetics used can reduce ST-segment elevation.

摘要

背景

在全身麻醉期间, Brugada综合征患者有发生ST段抬高加重后恶性心律失常的风险,这可能导致心源性猝死。Brugada综合征患者安全麻醉管理的方案尚未确立。

病例介绍

一名63岁男性,诊断为自发性1型Brugada图形,计划在全身麻醉下使用电视辅助胸腔镜手术进行胸膜活检。我们计划采用挥发性诱导和七氟醚及瑞芬太尼维持麻醉的全身麻醉方式。我们监测了ST段形态,并观察到在整个全身麻醉过程中ST段抬高持续减轻。

结论

本病例可能表明,Brugada综合征患者的安全麻醉管理取决于所用麻醉剂是否能降低ST段抬高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c341/10928048/37843a5d8eef/40981_2024_702_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c341/10928048/94c1ca18a395/40981_2024_702_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c341/10928048/37843a5d8eef/40981_2024_702_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c341/10928048/94c1ca18a395/40981_2024_702_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c341/10928048/37843a5d8eef/40981_2024_702_Fig2_HTML.jpg

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本文引用的文献

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Brugada Syndrome.Brugada 综合征。
JACC Clin Electrophysiol. 2022 Mar;8(3):386-405. doi: 10.1016/j.jacep.2021.12.001.
2
Propofol for Induction and Maintenance of Anesthesia in Patients With Brugada Syndrome: A Single-Center, 25-Year, Retrospective Cohort Analysis.丙泊酚用于布加综合征患者麻醉诱导与维持:一项单中心、25年回顾性队列分析
Anesth Analg. 2021 Jun 1;132(6):1645-1653. doi: 10.1213/ANE.0000000000005540.
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Mechanisms of Arrhythmias in the Brugada Syndrome. Brugada 综合征中的心律失常机制。
Int J Mol Sci. 2020 Sep 25;21(19):7051. doi: 10.3390/ijms21197051.
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Electrocardiographic Effects of Propofol versus Etomidate in Patients with Brugada Syndrome.普罗泊酚与依托咪酯对 Brugada 综合征患者心电图效应的比较。
Anesthesiology. 2020 Mar;132(3):440-451. doi: 10.1097/ALN.0000000000003030.
5
Brugada Syndrome: anesthetic considerations and management algorithm.Brugada 综合征:麻醉考虑因素和管理算法。
Minerva Anestesiol. 2019 Feb;85(2):173-188. doi: 10.23736/S0375-9393.18.13170-1. Epub 2018 Oct 30.
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General Anesthesia Attenuates Brugada Syndrome Phenotype Expression: Clinical Implications From a Prospective Clinical Trial.全身麻醉可减轻 Brugada 综合征表型表达:前瞻性临床试验的临床意义。
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7
HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013.遗传性原发性心律失常综合征患者诊断与管理的HRS/EHRA/APHRS专家共识声明:2013年5月由HRS、EHRA和APHRS认可,2013年6月由ACCF、AHA、PACES和AEPC认可。
Heart Rhythm. 2013 Dec;10(12):1932-63. doi: 10.1016/j.hrthm.2013.05.014. Epub 2013 Aug 30.
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