发展中国家社区药剂师关于孕期用药安全性的知识与实践：一项横断面研究
Knowledge and practice of community pharmacists regarding the safety of drugs during pregnancy: a cross-sectional study from a developing country.
作者信息
Koni Amer A, Qashoa Hamzah, Musa Abeer Abo, Masri Maen, Hazem Walaa, Taha Sari, Daifallah Aiman, Al-Jabi Samah W, Abushanab Amani S, Zyoud Sa'ed H
机构信息
Department of Clinical and Community Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.
Division of Clinical Pharmacy, Department of Hematology and Oncology, An-Najah National University Hospital, Nablus, 44839, Palestine.
出版信息
BMC Pregnancy Childbirth. 2024 Mar 11;24(1):189. doi: 10.1186/s12884-024-06393-3.
BACKGROUND
Drug use during pregnancy can cause unfavorable fetal and maternal outcomes. Information sharing is essential for pharmacists' role within intricate, modern healthcare systems. Community pharmacists (CPs) have demonstrated unsatisfactory knowledge across various pharmacological domains in most developing countries. This study aimed to explore the knowledge and practices of CPs regarding medications and herb safety during pregnancy.
METHODS
A cross-sectional study was conducted in a developing country using a self-administered questionnaire. A sample of CPs working in the northern governorates of the West Bank was selected by convenience sampling. The questionnaire included questions on sociodemographic characteristics, practices and knowledge. Descriptive and inferential statistics were calculated using the Statistical Package for the Social Sciences (SPSS) to analyze the data.
RESULTS
A total of 207 questionnaires were completed. Most respondents had only a bachelor's degree (89.9%) but did not participate in continuous professional development (CPD) (71.0%). Almost one-third of the CP workload involved dispensing drugs to pregnant women. The majority of the participants reported that they inquire about pregnancy status (59.9%), refer to scientific sources (82.6%), and contact a prescribing physician (51.2%) in cases of uncertainty. A higher knowledge score was associated with receiving a master's degree and CPD programs. Most CPs identified folic acid, paracetamol and amoxicillin as safe, while tetracycline, isotretinoin, enalapril, pseudoephedrine and ibuprofen were among the drugs mostly reported as unsafe. Castor oil, Senna, St. John's wort and ginseng were the most frequently reported herbs as unsafe.
CONCLUSIONS
Despite the gaps in knowledge about herb pharmacology, CPs demonstrated acceptable knowledge and practice regarding drug safety during pregnancy. CPD is recommended for addressing gaps in knowledge and practice. Future research evaluating knowledge and practice may benefit from developing a specific, accurate, validated instrument.
背景
孕期用药会导致不良的胎儿和母体结局。在复杂的现代医疗体系中，信息共享对药剂师的角色至关重要。在大多数发展中国家，社区药剂师（CPs）在各个药理学领域的知识水平都不尽人意。本研究旨在探讨社区药剂师在孕期用药和草药安全性方面的知识与实践情况。
方法
在一个发展中国家采用自填式问卷进行横断面研究。通过方便抽样选取在约旦河西岸北部省份工作的社区药剂师样本。问卷包括社会人口学特征、实践和知识方面的问题。使用社会科学统计软件包（SPSS）计算描述性和推断性统计数据以分析数据。
结果
共完成207份问卷。大多数受访者仅有学士学位（89.9%），但未参加持续专业发展（CPD）（71.0%）。社区药剂师近三分之一的工作量涉及为孕妇配药。大多数参与者报告说，他们会询问怀孕状况（59.9%），参考科学资料（82.6%），并在不确定的情况下联系开处方的医生（51.2%）。较高的知识得分与获得硕士学位和参加CPD项目有关。大多数社区药剂师认为叶酸、对乙酰氨基酚和阿莫西林是安全的，而四环素、异维甲酸、依那普利、伪麻黄碱和布洛芬是最常被报告为不安全的药物。蓖麻油、番泻叶、圣约翰草和人参是最常被报告为不安全的草药。
结论
尽管在草药药理学知识方面存在差距，但社区药剂师在孕期用药安全方面表现出了可接受的知识和实践。建议通过CPD来弥补知识和实践方面的差距。未来评估知识和实践的研究可能会受益于开发一种特定、准确、经过验证的工具。
Zotero 插件