Xia Tian, Zhu Yuting, Li Kaiqiang, Hao Ke, Chai Yingqian, Jiang Hongyi, Lou Chao, Yu Jiachen, Yang Wei, Wang Jilong, Deng Junjie, Wang Zhen
Laboratory Medicine Center, Allergy Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital ，Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, China.
Joint Centre of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
J Nanobiotechnology. 2024 Mar 11;22(1):103. doi: 10.1186/s12951-024-02374-y.
Rheumatoid arthritis (RA) is a prevalent inflammatory autoimmune disease characterised by persistent inflammation and joint damage with elevated levels of reactive oxygen species (ROS). Current treatment modalities for RA have significant limitations, including poor bioavailability, severe side effects, and inadequate targeting of inflamed joints. Herein, we synthesised cerium/manganese oxide nanoparticles (NPs) as efficient drug carriers with antioxidant and catalytic-like functions that can eliminate ROS to facilitate the polarization of macrophages phenotype from M1 to M2 and alleviate inflammation. Methotrexate (MTX), a first-line RA medication, was loaded into the NPs, which were further modified with bovine serum albumin (BSA) and integrated into dissolving hyaluronic acid-based microneedles (MNs) for transdermal delivery.
This innovative approach significantly enhanced drug delivery efficiency, reduced RA inflammation, and successfully modulated macrophage polarization toward an anti-inflammatory phenotype.
This research not only presents a promising drug delivery strategy for RA but also contributes broadly to the field of immune disease treatment by offering an advanced approach for macrophage phenotypic reprogramming.
类风湿性关节炎（RA）是一种常见的炎症性自身免疫疾病，其特征为持续炎症和关节损伤，伴有活性氧（ROS）水平升高。目前用于治疗RA的方法存在显著局限性，包括生物利用度差、严重副作用以及对炎症关节的靶向性不足。在此，我们合成了具有抗氧化和类催化功能的铈/锰氧化物纳米颗粒（NPs）作为高效药物载体，其可消除ROS以促进巨噬细胞表型从M1向M2极化并减轻炎症。将一线RA药物甲氨蝶呤（MTX）载入NPs，并用牛血清白蛋白（BSA）进一步修饰，然后整合到基于透明质酸的溶蚀性微针（MNs）中用于经皮给药。
这种创新方法显著提高了药物递送效率，减轻了RA炎症，并成功调节巨噬细胞向抗炎表型极化。
本研究不仅为RA提供了一种有前景的药物递送策略，还通过提供一种先进的巨噬细胞表型重编程方法，为免疫疾病治疗领域做出了广泛贡献。
