Chen Junzhi, Huang Yan, Li Xiaolin
Division of Nephrology, South China Hospital of Shenzhen University, Shenzhen, China.
National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Brain Behav. 2024 Mar;14(3):e3467. doi: 10.1002/brb3.3467.
The relationship of lymphocyte to high-density lipoprotein ratio (LHR) with depression remains uncertain. We aimed to evaluate the association between LHR and depression in US adults.
In this cross-sectional study, a total of 4216 participants were enrolled from the National Health and Nutrition Examination Survey (2015-2018). Depressive symptoms were measured with the Patient Health Questionnaire-9 (PHQ-9). Participants were classified as having depression if PHQ-9 scores were ≥10. Multiple logistic regression models were used to explore the relationship between the LHR and depression.
Overall, the LHR was significantly associated with depression (per standard deviation increment; adjusted odds ratio (OR), 1.31; 95% confidence interval (CI) [1.14, 1.50]) after adjusted potential variables. Interactions between LHR with metabolic syndrome (MetS) and body mass index (BMI) on the risk of depression were found in stratified analysis (p for interaction < .05).
A higher level of LHR was significantly associated with higher odds of having depression in US adults, and it was strengthened in participants with MetS or BMI ranging from 25 to 30 kg/m .
淋巴细胞与高密度脂蛋白比值（LHR）和抑郁症之间的关系尚不确定。我们旨在评估美国成年人中LHR与抑郁症之间的关联。
在这项横断面研究中，从国家健康与营养检查调查（2015 - 2018年）中招募了总共4216名参与者。使用患者健康问卷-9（PHQ-9）测量抑郁症状。如果PHQ-9得分≥10，则参与者被归类为患有抑郁症。使用多元逻辑回归模型来探讨LHR与抑郁症之间的关系。
总体而言，在调整潜在变量后，LHR与抑郁症显著相关（每标准差增加；调整后的优势比（OR）为1.31；95%置信区间（CI）[1.14, 1.50]）。在分层分析中发现LHR与代谢综合征（MetS）和体重指数（BMI）之间在抑郁症风险上存在相互作用（交互作用p <.05）。
在美国成年人中，较高水平的LHR与患抑郁症的较高几率显著相关，并且在患有MetS或BMI在25至30 kg/m²之间的参与者中这种关联更强。
