鞘氨醇-1-磷酸受体4（S1PR4）作为皮肤黑色素瘤生物标志物的表达及预后作用
Expression and prognostic role of sphingosine 1-phosphate receptor 4 (S1PR4) as a biomarker of skin cutaneous melanoma.
作者信息
Wang Zi, Pan Fei, Zhang Guangzhong
机构信息
Beijing University of Chinese Medicine, Beijing, China.
Department of Dermatology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
出版信息
Heliyon. 2024 Mar 2;10(5):e27505. doi: 10.1016/j.heliyon.2024.e27505. eCollection 2024 Mar 15.
BACKGROUND
Skin cutaneous melanoma (SKCM) is one of the most lethal skin malignancies worldwide. Sphingosine 1-phosphate (S1P) regulates tumor cells through S1P receptors (S1PRs). Unlike , whose anti-apoptotic effects have been widely studied, the regulatory effect of on tumors has not been studied extensively. In this study, we aimed to investigate the correlation between expression and survival, clinical manifestations, tumor microenvironment, and immune infiltration in patients with SKCM.
RESULTS
Low expression was associated with poor prognosis in patients with SKCM. Patients in the high-expression group had significantly longer disease survival and progression-free survival than those in the low-expression group.
CONCLUSION
High expression was highly associated with better prognosis and milder clinical manifestations; thus, may be used as a prognostic marker to help physicians monitor patients with SKCM.
背景
皮肤黑色素瘤（SKCM）是全球最致命的皮肤恶性肿瘤之一。1-磷酸鞘氨醇（S1P）通过S1P受体（S1PRs）调节肿瘤细胞。与抗凋亡作用已被广泛研究的[未提及的物质]不同，[未提及的物质]对肿瘤的调节作用尚未得到广泛研究。在本研究中，我们旨在探讨[未提及的物质]表达与SKCM患者生存、临床表现、肿瘤微环境及免疫浸润之间的相关性。
结果
SKCM患者中[未提及的物质]低表达与预后不良相关。高表达组患者的疾病生存期和无进展生存期显著长于低表达组患者。
结论
[未提及的物质]高表达与较好的预后和较轻的临床表现高度相关；因此，[未提及的物质]可作为一种预后标志物，帮助医生监测SKCM患者。
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