Key Laboratory of Rubber-Plastics of Ministry of Education/Shandong Province (QUST), School of Polymer Science & Engineering, Qingdao University of Science & Technology, 53-Zhengzhou Road, Qingdao, 266042, PR China.
Biomater Sci. 2024 Apr 16;12(8):2019-2032. doi: 10.1039/d3bm02070c.
Organic fluorescent materials (OFMs) play a crucial role in the development of biosensors, enabling the extraction of biochemical information within cells and organisms, extending to the human body. Concurrently, OFM biosensors contribute significantly to the progress of modern medical and biological research. However, the practical applications of OFM biosensors face challenges, including issues related to low resolution, dispersivity, and stability. To overcome these challenges, scientists have introduced interactive elements to enhance the order of OFMs. Highly-ordered assembled OFMs represent a novel material type applied to biosensors. In comparison to conventional fluorescent materials, highly-ordered assembled OFMs typically exhibit robust anti-diffusion properties, high imaging contrast, and excellent stability. This approach has emerged as a promising method for effectively tracking bio-signals, particularly in the non-invasive monitoring of chronic diseases. This review introduces several highly-ordered assembled OFMs used in biosensors and also discusses various interactions that are responsible for their assembly, such as hydrogen bonding, π-π interaction, dipole-dipole interaction, and ion electrostatic interaction. Furthermore, it delves into the various applications of these biosensors while addressing the drawbacks that currently limit their commercial application. This review aims to provide a theoretical foundation for designing high-performance, highly-ordered assembled OFM biosensors suitable for practical applications. Additionally, it sheds light on the evolving trends in OFM biosensors and their application fields, offering valuable insights into the future of this dynamic research area.
有机荧光材料（OFMs）在生物传感器的发展中起着至关重要的作用，使人们能够提取细胞和生物体内的生化信息，并扩展到人体。同时，OFM 生物传感器为现代医学和生物研究的进展做出了重大贡献。然而，OFM 生物传感器的实际应用面临着一些挑战，包括分辨率、分散性和稳定性等问题。为了克服这些挑战，科学家们引入了相互作用的元素来提高 OFMs 的有序性。高度有序组装的 OFMs 是一种应用于生物传感器的新型材料。与传统荧光材料相比，高度有序组装的 OFMs 通常具有较强的抗扩散性能、高成像对比度和优异的稳定性。这种方法已成为有效跟踪生物信号的一种有前途的方法，特别是在慢性病的非侵入性监测中。本综述介绍了几种用于生物传感器的高度有序组装的 OFMs，并讨论了导致它们组装的各种相互作用，如氢键、π-π 相互作用、偶极-偶极相互作用和离子静电相互作用。此外，还探讨了这些生物传感器的各种应用，同时解决了目前限制其商业应用的缺点。本综述旨在为设计适用于实际应用的高性能、高度有序组装的 OFM 生物传感器提供理论基础。此外，它还揭示了 OFM 生物传感器及其应用领域的发展趋势，为这个充满活力的研究领域的未来提供了有价值的见解。
