Clin Lab. 2024 Mar 1;70(3). doi: 10.7754/Clin.Lab.2023.230809.
The goal was to report a rare case of lymphadenitis caused by Corynebacterium tuberculostearicum, and the laboratory's coping approach in the isolation and identification of this rare pathogen to improve the understanding of the disease.
Lymph node biopsy was performed in a patient with suspected tuberculous lymphadenitis, and the biopsy tissue was isolated and cultured.
The culture was Gram positive Corynebacterium, which was identified as Corynebacterium tuberculostearicum by microbial mass spectrometry and 16S rRNA gene sequencing. Antimicrobial susceptibility test showed that the drug was sensitive to daptomycin, doxycycline, gentamicin, linezolid, vancomycin, and meropenem, but resistant to ciprofloxacin, clindamycin, erythromycin, rifampicin, compound sulfamethoxazole, ceftriaxone, and cefepime.
This is a case of Corynebacterium tuberculostearicum infection. Case reports of Corynebacterium tuberculostearicum infection are relatively rare in China. Through case study, we can provide help for laboratory isolation, identification, clinical diagnosis, and treatment.
本研究旨在报告一例罕见的由结核棒状杆菌引起的淋巴结炎，并介绍实验室在分离和鉴定这种罕见病原体方面的应对方法，以提高对该疾病的认识。
对疑似结核性淋巴结炎患者进行淋巴结活检，并对活检组织进行分离和培养。
培养出革兰阳性棒状杆菌，经微生物质谱和 16S rRNA 基因测序鉴定为结核棒状杆菌。药敏试验显示，该药物对达托霉素、强力霉素、庆大霉素、利奈唑胺、万古霉素和美罗培南敏感，但对环丙沙星、克林霉素、红霉素、利福平、复方磺胺甲噁唑、头孢曲松和头孢吡肟耐药。
这是一例结核棒状杆菌感染。中国结核棒状杆菌感染的病例报告相对较少。通过病例研究，可以为实验室分离、鉴定、临床诊断和治疗提供帮助。
