Rahamouz-Haghighi Samaneh, Sharafi Ali
Department of Plant Production and Genetics, University of Zanjan, Zanjan, Iran.
Department of Pharmaceutical Biotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
Nat Prod Res. 2025 May;39(9):2658-2662. doi: 10.1080/14786419.2024.2326993. Epub 2024 Mar 12.
root extracts were used for analysis by Gas Chromatography-Mass Spectrometry (GC-MS). The anticancer and antibacterial functions of extracts were also investigated. The dichloromethane extract of had the highest inhibitory effect against (18.00 ± 1.4 mm) at 100 mg/mL concentration. The lowest MIC was also achieved for treated with dichloromethane extract of (1.5 mg/mL). The minimum MBC (2 mg/mL) was observed for dichloromethane extract of root against . IC values of dichloromethane extracts of root (184.84 μg/mL) against HCT116 were lower than the ethyl acetate and butanol extracts (212.41 μg/mL and 223.93 μg/mL) at 72h. The butanol extract exhibited the most IC value on HEK293 (748.19 μg/mL). The biological properties of extracts may be assigned to the presence of numerous compounds detected in GC/MS analysis including n-Hexadecanoic acid, Linolenic acid, Palmitic acid, methyl ester, Stearic acid.
根提取物用于气相色谱-质谱联用（GC-MS）分析。还研究了提取物的抗癌和抗菌功能。在100mg/mL浓度下，[植物名称]的二氯甲烷提取物对[细菌名称]具有最高的抑制作用（18.00±1.4mm）。用[植物名称]的二氯甲烷提取物处理[细菌名称]时，最低抑菌浓度（MIC）也达到了（1.5mg/mL）。观察到[植物名称]根的二氯甲烷提取物对[细菌名称]的最小杀菌浓度（MBC）为2mg/mL。在72小时时，[植物名称]根的二氯甲烷提取物对HCT116的半数抑制浓度（IC）值（184.84μg/mL）低于乙酸乙酯和丁醇提取物（212.41μg/mL和223.93μg/mL）。丁醇提取物对HEK293的IC值最高（748.19μg/mL）。[植物名称]提取物的生物学特性可能归因于GC/MS分析中检测到的多种化合物，包括正十六烷酸、亚麻酸、棕榈酸甲酯、硬脂酸。
