Ek Lena, Elwin Marie, Neander Kerstin
Department of Rehabilitation, Hässleholm Hospital, Hässleholm, Sweden.
Faculty of Medicine and Health, University Health Care Research Centre, Örebro University, Örebro, Sweden.
Appl Neuropsychol Adult. 2024 Mar 12:1-11. doi: 10.1080/23279095.2024.2325546.
This study is part of a longitudinal research program, in which patients diagnosed with low-grade gliomas (LGG: = 13), as well as healthy controls ( = 13), were consecutively recruited and neuropsychologically followed for 7 years. The patients are followed up regardless of variations in treatment. A composite score is used (Global Deficit Score: GDS) included cognitive measures where at least five patients had a negative change: information processing speed, speed of naming, construction ability, verbal fluency, non-verbal thinking, and immediate non-verbal memory. The most important finding in this 7-year follow-up study is that two-thirds of the patients developed cognitive impairment. The remaining third of the patients showed stability in their cognitive ability and were still alive 17 years after diagnosis. Younger patients with tumors in the right frontal or posterior regions showed a more favorable development. Patients with frontal tumors and a declined GDS show also significant changes in executive functions. Given the limited number, no firm conclusions can be drawn regarding the impact of tumor localization. The impact of LGG on cognition and the survival time after diagnosis varies considerably between patients. However, most of the patients (69%) showed cognitive impairment during the seven years we followed them.
本研究是一项纵向研究项目的一部分，在该项目中，连续招募了被诊断为低级别胶质瘤的患者（LGG：= 13）以及健康对照者（= 13），并对他们进行了7年的神经心理学随访。无论治疗方式如何变化，都会对患者进行随访。使用了一个综合评分（整体缺陷评分：GDS），其中包括认知测量，至少五名患者出现了负面变化：信息处理速度、命名速度、构建能力、语言流畅性、非语言思维和即时非语言记忆。这项7年随访研究中最重要的发现是，三分之二的患者出现了认知障碍。其余三分之一的患者认知能力保持稳定，在诊断后17年仍然存活。右侧额叶或后部区域有肿瘤的年轻患者显示出更有利的病情发展。额叶肿瘤且GDS下降的患者在执行功能方面也有显著变化。鉴于样本数量有限，关于肿瘤定位的影响无法得出确凿结论。LGG对认知和诊断后存活时间的影响在患者之间差异很大。然而，在我们随访的七年中，大多数患者（69%）出现了认知障碍。
