Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Key Laboratory of Tropical Biological Resources of Ministry Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China.
J Agric Food Chem. 2024 Mar 27;72(12):6424-6431. doi: 10.1021/acs.jafc.4c00780. Epub 2024 Mar 12.
Six new 9-carbazole derivatives (-) and nine previously reported compounds (-) were isolated from a fermented solid medium of the Thailand mangrove-derived strain, OUCMDZ-5511, under fluoride stress. Compounds -, , and were exclusively present in the fluoride-supplemented fermentation medium, while compounds -, , and were newly discovered natural products. The molecular structures of the compounds were identified by a spectroscopic analysis. The new compound displayed antiquorum sensing activity against ATCC 12472 by reducing the violacein production and inhibiting the biofilm formation in a concentration-dependent manner. The study revealed that compound could be a novel potential inhibitor of quorum sensing.
六种新的 9-咔唑衍生物（-）和九种先前报道的化合物（-）从泰国红树林来源的 菌株的发酵固体培养基中分离得到，该菌株在氟化物胁迫下培养。化合物 - 、- 和 - 仅存在于添加氟化物的发酵培养基中，而化合物 - 、- 和 - 是新发现的天然产物。通过光谱分析确定了化合物的分子结构。新化合物 对 ATCC 12472 表现出抗群体感应活性，通过降低紫色素的产生并以浓度依赖的方式抑制生物膜的形成。该研究表明，化合物 可能是一种新型潜在的群体感应抑制剂。
