Vičaitė Gabija, Barišauskaitė Liveta, Bakstytė Viktorija, Siesky Brent, Verticchio Vercellin Alice, Janulevičienė Ingrida
Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, LT-50161 Kaunas, Lithuania.
Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Diagnostics (Basel). 2024 Feb 29;14(5):515. doi: 10.3390/diagnostics14050515.
(1) Background: Growing evidence suggests impairment of ocular blood flow in open-angle glaucoma (OAG) pathology, but little is known about the effect of an impaired cardiovascular supply on the structural and vascular parameters of the retina. This study aims to investigate the variations of these parameters in OAG patients compared to patients undergoing cardiac surgery (CS) with cardiopulmonary bypass. (2) Methods: Prospective observational study with 82 subjects (30 controls, 33 OAG patients, and 19 CS patients) who underwent ophthalmological assessment by swept-source OCT and CDI in one randomly selected eye. (3) Results: In the CS group, OA and SPCA PSV and EDV were significantly lower, OA and SPCA RI were significantly higher compared to the OAG and healthy subjects ( = 0.000-0.013), and SPCA EDV correlated with linear CDR (r = -0.508, = 0.027). Temporal ONH sectors of GCL++ and GCL+ layers in the CS group did not differ significantly compared to the OAG patients ( = 0.085 and = 0.220). The CS patients had significantly thinner GCL++ and GCL+ layers in the inner sectors ( = 0.000-0.038) compared to healthy subjects, and these layers correlated with the CRA PSV, EDV, and RI and SPCA PSV ( = 0.005-0.047). (4) Conclusions: CS patients had lower vascular and structural parameters in the ONH, and macula compared to the healthy controls that were similar to persons with OAG.
(1) 背景：越来越多的证据表明开角型青光眼（OAG）病理过程中存在眼部血流受损的情况，但关于心血管供应受损对视网膜结构和血管参数的影响却知之甚少。本研究旨在调查与接受体外循环心脏手术（CS）的患者相比，OAG患者这些参数的变化。(2) 方法：对82名受试者（30名对照者、33名OAG患者和19名CS患者）进行前瞻性观察研究，在一只随机选择的眼睛上通过扫频源光学相干断层扫描（OCT）和彩色多普勒成像（CDI）进行眼科评估。(3) 结果：与OAG患者和健康受试者相比，CS组的眼动脉（OA）和睫状后短动脉（SPCA）的峰值收缩速度（PSV）和舒张末期速度（EDV）显著降低，OA和SPCA的阻力指数（RI）显著升高（P = 0.000 - 0.013），且SPCA的EDV与线性杯盘比（CDR）相关（r = -0.508，P = 0.027）。与OAG患者相比，CS组颞侧视神经乳头（ONH）的神经节细胞层加内核层（GCL++）和神经节细胞层（GCL+）各扇形区域差异无统计学意义（P = 0.085和P = 0.220）。与健康受试者相比，CS患者在内侧扇形区域的GCL++和GCL+层显著变薄（P = 0.000 - 0.038），且这些层与视网膜中央动脉（CRA）的PSV、EDV、RI以及SPCA的PSV相关（P = 0.005 - 0.047）。(4) 结论：与健康对照组相比，CS患者的视神经乳头和黄斑区的血管及结构参数较低，这与OAG患者相似。
