Yan Qiyue, Gao Chuanzhou, Li Mei, Lan Rui, Wei Shaohan, Fan Runsong, Cheng Wei
Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, China.
Int J Mol Sci. 2024 Feb 27;25(5):2719. doi: 10.3390/ijms25052719.
The transient receptor potential (TRP) ion channels act as cellular sensors and mediate a plethora of physiological processes, including somatosensation, proliferation, apoptosis, and metabolism. Under specific conditions, certain TRP channels are involved in inflammation and immune responses. Thus, focusing on the role of TRPs in immune system cells may contribute to resolving inflammation. In this review, we discuss the distribution of five subfamilies of mammalian TRP ion channels in immune system cells and how these ion channels function in inflammatory mechanisms. This review provides an overview of the current understanding of TRP ion channels in mediating inflammation and may offer potential avenues for therapeutic intervention.
瞬时受体电位（TRP）离子通道作为细胞传感器，介导众多生理过程，包括躯体感觉、增殖、凋亡和代谢。在特定条件下，某些TRP通道参与炎症和免疫反应。因此，关注TRP在免疫系统细胞中的作用可能有助于解决炎症问题。在这篇综述中，我们讨论了哺乳动物TRP离子通道五个亚家族在免疫系统细胞中的分布，以及这些离子通道在炎症机制中的作用。这篇综述概述了目前对TRP离子通道介导炎症的理解，并可能为治疗干预提供潜在途径。
