Jahn Jacob, Ehlen Quinn T, Kaplan Lee, Best Thomas M, Meng Zhipeng, Huang Chun-Yuh
University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Department of Orthopedics, University of Miami, Miami, FL 33136, USA.
Bioengineering (Basel). 2024 Sep 27;11(10):972. doi: 10.3390/bioengineering11100972.
In this review, we explore the intricate relationship between glucose metabolism and mechanotransduction pathways, with a specific focus on the role of the Hippo signaling pathway in chondrocyte pathophysiology. Glucose metabolism is a vital element in maintaining proper chondrocyte function, but it has also been implicated in the pathogenesis of osteoarthritis (OA) via the induction of pro-inflammatory signaling pathways and the establishment of an intracellular environment conducive to OA. Alternatively, mechanotransduction pathways such as the Hippo pathway possess the capacity to respond to mechanical stimuli and have an integral role in maintaining chondrocyte homeostasis. However, these mechanotransduction pathways can be dysregulated and potentially contribute to the progression of OA. We discussed how alterations in glucose levels may modulate the Hippo pathway components via a variety of mechanisms. Characterizing the interaction between glucose metabolism and the Hippo pathway highlights the necessity of balancing both metabolic and mechanical signaling to maintain chondrocyte health and optimal functionality. Furthermore, this review demonstrates the scarcity of the literature on the relationship between glucose metabolism and mechanotransduction and provides a summary of current research dedicated to this specific area of study. Ultimately, increased research into this topic may elucidate novel mechanisms and relationships integrating mechanotransduction and glucose metabolism. Through this review we hope to inspire future research into this topic to develop innovative treatments for addressing the clinical challenges of OA.
在本综述中，我们探讨了葡萄糖代谢与机械转导途径之间的复杂关系，特别关注 Hippo 信号通路在软骨细胞病理生理学中的作用。葡萄糖代谢是维持软骨细胞正常功能的重要因素，但它也通过诱导促炎信号通路和建立有利于骨关节炎（OA）的细胞内环境，参与了骨关节炎的发病机制。另外，像 Hippo 通路这样的机械转导途径具有对机械刺激作出反应的能力，并且在维持软骨细胞稳态中起着不可或缺的作用。然而，这些机械转导途径可能会失调，并可能导致 OA 的进展。我们讨论了葡萄糖水平的变化如何通过多种机制调节 Hippo 通路的组成部分。表征葡萄糖代谢与 Hippo 通路之间的相互作用凸显了平衡代谢和机械信号以维持软骨细胞健康和最佳功能的必要性。此外，本综述表明关于葡萄糖代谢与机械转导之间关系的文献稀缺，并提供了针对这一特定研究领域的当前研究总结。最终，对该主题的更多研究可能会阐明整合机械转导和葡萄糖代谢的新机制和关系。通过本综述，我们希望激发对该主题的未来研究，以开发创新疗法来应对 OA 的临床挑战。
