文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

美国癌症幸存者中全身炎症反应指数和预后营养指数与生存率的联合关联

Combined association of systemic inflammatory response index and prognostic nutritional index with survival among US cancer survivors.

作者信息

Luo Bingqing, Tan Xiaoyan, Chen Lin, Zhou Kang, Lou Shifeng

机构信息

Department of Hematology, The Second Affiliated Hospital, Chongqing Medical University, Jiangnan, Chongqing, 400000, China.

出版信息

BMC Cancer. 2025 Jul 1;25(1):1114. doi: 10.1186/s12885-025-14509-x.

DOI:10.1186/s12885-025-14509-x
PMID:40597939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12210657/
Abstract

BACKGROUND: Systemic inflammation and nutritional status play critical roles in determining clinical outcomes across multiple disease entities, particularly malignancies. Significantly, these two pathophysiological factors exhibit dynamic interplay through shared pathobiological mechanisms. This study sought to investigate the independent and combined prognostic capacity of the systemic inflammatory response index (SIRI) and prognostic nutritional index (PNI) in predicting all-cause, cancer-specific, and non-cancer mortality among cancer survivors. METHODS: Utilizing the National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2018, 3,289 adult cancer survivors (weighted population: 20,795,493) were analyzed. Restricted cubic splines (RCS) delineated mortality risk nonlinearity. Survival trajectories were assessed via Kaplan-Meier (KM) analysis with complex survey adjustments. Weighted Cox proportional hazards models quantified independent and joint associations. RESULTS: Eight hundred seventy-four deaths were identified over a median follow-up of 6.5 years. By RCS analyses, SIRI exhibited a linear association with all-cause mortality, whereas PNI demonstrated a nonlinear relationship with all-cause mortality. Weighted Cox regression analysis demonstrated increased all-cause, cancer-specific, and non-cancer mortality risks in cancer survivors with high-SIRI or with undernutrition (PNI ≤ 48). Joint analysis showed that cancer survivors with concurrent high-SIRI and undernutrition had the highest risk for all-cause (HR 3.169, 95%CI 2.324-4.321), cancer-specific (HR 2.578, 95%CI 1.308-5.080) and non-cancer (HR 2.197, 95%CI 1.480-3.261) mortality, respectively, relative to the reference group with concurrent low-SIRI and PNI > 48. Subgroup and interaction analysis confirmed the stability of the core results. CONCLUSION: SIRI and PNI emerged as independent prognostic predictors with synergistic mortality prediction capacity in cancer survivors. Cancer survivors with concurrent high level of systemic inflammation and poor nutritional status was associated with the highest mortality risk for all-cause, cancer-specific, and non-cancer.

摘要

背景：全身炎症和营养状况在决定多种疾病实体（尤其是恶性肿瘤）的临床结局中起着关键作用。重要的是，这两个病理生理因素通过共同的病理生物学机制表现出动态相互作用。本研究旨在探讨全身炎症反应指数（SIRI）和预后营养指数（PNI）在预测癌症幸存者全因、癌症特异性和非癌症死亡率方面的独立及联合预后能力。 方法：利用2005年至2018年的美国国家健康与营养检查调查（NHANES）数据，对3289名成年癌症幸存者（加权人口：20795493）进行了分析。受限立方样条（RCS）描绘了死亡风险的非线性。通过带有复杂调查调整的Kaplan-Meier（KM）分析评估生存轨迹。加权Cox比例风险模型量化了独立和联合关联。 结果：在中位随访6.5年期间，共确定了874例死亡病例。通过RCS分析，SIRI与全因死亡率呈线性关联，而PNI与全因死亡率呈非线性关系。加权Cox回归分析表明，高SIRI或营养不良（PNI≤48）的癌症幸存者全因、癌症特异性和非癌症死亡风险增加。联合分析显示，与同时具有低SIRI和PNI>48的参照组相比，同时具有高SIRI和营养不良的癌症幸存者全因（HR 3.169，95%CI 2.324-4.321）、癌症特异性（HR 2.578，95%CI 1.308-5.080）和非癌症（HR 2.197，95%CI 1.480-3.261）死亡率最高。亚组和交互分析证实了核心结果的稳定性。 结论：SIRI和PNI是癌症幸存者中具有协同死亡预测能力的独立预后预测指标。同时具有高水平全身炎症和不良营养状况的癌症幸存者全因、癌症特异性和非癌症死亡风险最高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2c/12210657/05f57b2dc1ab/12885_2025_14509_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2c/12210657/909e5a7a2cfe/12885_2025_14509_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2c/12210657/792b284b8130/12885_2025_14509_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2c/12210657/a95c201fef87/12885_2025_14509_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2c/12210657/95ad4455184b/12885_2025_14509_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2c/12210657/198ff8dd7793/12885_2025_14509_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2c/12210657/05f57b2dc1ab/12885_2025_14509_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2c/12210657/909e5a7a2cfe/12885_2025_14509_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2c/12210657/792b284b8130/12885_2025_14509_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2c/12210657/a95c201fef87/12885_2025_14509_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2c/12210657/95ad4455184b/12885_2025_14509_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2c/12210657/198ff8dd7793/12885_2025_14509_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2c/12210657/05f57b2dc1ab/12885_2025_14509_Fig6_HTML.jpg

相似文献

[1]
Combined association of systemic inflammatory response index and prognostic nutritional index with survival among US cancer survivors.

BMC Cancer. 2025-7-1

[2]
Elevated pulse wave velocity as a marker of arterial stiffness and its association with mortality in US adults.

Sci Rep. 2025-7-2

[3]
Correlation between CBC-derived inflammatory indicators and all-cause mortality with rheumatoid arthritis: a population-based study.

Front Med (Lausanne). 2025-6-10

[4]
Prognostic implications of systemic immune-inflammation index and systemic inflammation response index in hemodialysis patients.

BMC Nephrol. 2025-7-1

[5]
NHANES 2005-2018 data reveal high albumin-bilirubin scores are associated with depression.

BMC Psychiatry. 2025-7-1

[6]
Dietary inflammatory index and mortality in middle-aged and elderly patients with metabolic syndrome.

Diabetol Metab Syndr. 2025-7-2

[7]
The relationship between the Geriatric Nutritional Risk Index and all-cause mortality in patients with peripheral artery disease.

PLoS One. 2025-6-27

[8]
Sitting Time, Leisure-Time Physical Activity, and Risk of Mortality Among US Stroke Survivors: A Prospective Cohort Study From the NHANES 2007 to 2018.

Stroke. 2025-7

[9]
Mortality Outcomes for Survivors of Cancer With Food Insecurity in the US.

JAMA Health Forum. 2025-6-7

[10]
Threshold effect of prognostic nutritional index on mortality in geriatric hip fracture patients.

Sci Rep. 2025-7-1

引用本文的文献

[1]
Predictive Value of the Cally Score in Determining Surgical Strategy for Complicated Left-Sided Colonic Diverticulitis: A Retrospective Cohort Study.

Medicina (Kaunas). 2025-8-13

本文引用的文献

[1]
Optimised Workflows for Profiling the Metabolic Fluxes in Suspension vs. Adherent Cancer Cells via Seahorse Technology.

Int J Mol Sci. 2024-12-27

[2]
Prognostic and clinicopathological role of pretreatment systemic inflammation response index (SIRI) in gastric cancer: a systematic review and meta-analysis.

World J Surg Oncol. 2024-12-20

[3]
Obesity-induced tissue alterations resist weight loss: A mechanistic review.

Diabetes Obes Metab. 2024-8

[4]
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.

CA Cancer J Clin. 2024

[5]
Systemic Inflammatory Response Index (SIRI) is associated with all-cause mortality and cardiovascular mortality in population with chronic kidney disease: evidence from NHANES (2001-2018).

Front Immunol. 2024

[6]
The Killer's Web: Interconnection between Inflammation, Epigenetics and Nutrition in Cancer.

Int J Mol Sci. 2024-2-27

[7]
Cholesterol-modified prognostic nutritional index (CPNI) as an effective tool for assessing the nutrition status and predicting survival in patients with breast cancer.

BMC Med. 2023-12-21

[8]
Malnutrition in cancer patients: Causes, consequences and treatment options.

Eur J Surg Oncol. 2024-5

[9]
Prognostic nutritional index as a prognostic biomarker for gastrointestinal cancer patients treated with immune checkpoint inhibitors.

Front Immunol. 2023

[10]
Inflammation and Nutrition: Friend or Foe?

Nutrients. 2023-2-25

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索