Doctoral School, Discipline of Genetics, "Victor Babes" University of Medicine and Pharmacy, Piata Eftimie Murgu 2, 300041 Timisoara, Romania.
Faculty of Animal Husbandry and Biotechnologies, University of Agricultural Sciences and Veterinary Medicine of Banat, Calea Aradului 119, 300645 Timisoara, Romania.
Int J Mol Sci. 2024 Mar 4;25(5):2986. doi: 10.3390/ijms25052986.
Cardiovascular diseases (CVDs) are responsible for approximately 17.9 million deaths every year. There is growing evidence that circular RNAs (circRNAs) may play a significant role in the early diagnosis and treatment of cardiovascular diseases. As regulatory molecules, circular RNAs regulate gene expression, interact with proteins and miRNAs, and are translated into proteins that play a key role in a wide variety of biological processes, including the division and proliferation of cells, as well as the growth and development of individuals. An overview of the properties, expression profiles, classification, and functions of circRNAs is presented here, along with an explanation of their implications in cardiovascular diseases including heart failure, hypertension, ischemia/reperfusion injury, myocardial infarction, cardiomyopathies, atherosclerosis, and arrhythmia.
心血管疾病（CVDs）每年导致约 1790 万人死亡。越来越多的证据表明，环状 RNA（circRNAs）可能在心血管疾病的早期诊断和治疗中发挥重要作用。作为调节分子，环状 RNA 调节基因表达，与蛋白质和 miRNA 相互作用，并被翻译成蛋白质，在包括细胞分裂和增殖以及个体生长和发育在内的广泛的生物过程中发挥关键作用。本文综述了 circRNAs 的特性、表达谱、分类和功能，并解释了它们在心血管疾病中的作用，包括心力衰竭、高血压、缺血/再灌注损伤、心肌梗死、心肌病、动脉粥样硬化和心律失常。
