环状 RNA 作为心血管疾病的诊断和治疗靶点。
Circular RNAs as a Diagnostic and Therapeutic Target in Cardiovascular Diseases.
机构信息
Laboratory of Biochemistry and Molecular Biology Applied to the Exercise, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo 05508-030, Brazil.
出版信息
Int J Mol Sci. 2023 Jan 21;24(3):2125. doi: 10.3390/ijms24032125.
Circular RNAs (circRNAs) are a family of noncoding RNAs (ncRNAs) that are endogenous and widely distributed in different species, performing several functions, mainly their association with microRNAs (miRNAs) and RNA-binding proteins. CVDs remain the leading cause of death worldwide; therefore, the development of new therapies and strategies, such as gene therapies or nonpharmacological therapies, with low cost, such as physical exercise, to alleviate these diseases is of extreme importance for society. With increasing evidence of ncRNA participating in the progression of CVDs, several studies have reported these RNAs as promising targets for diagnosis and treatment. There are several studies of CVDs and the role of miRNAs and lncRNAs; however, little is known about the new class of RNAs, called circRNAs, and CVDs. In this mini review, we focus on the mechanisms of circRNAs and CVDs.
环状 RNA（circRNAs）是一类内源性的非编码 RNA（ncRNAs），广泛存在于不同物种中，具有多种功能，主要与其与 microRNAs（miRNAs）和 RNA 结合蛋白的结合有关。心血管疾病仍然是全球范围内的主要死因；因此，开发新的治疗方法和策略，如基因治疗或非药物治疗，具有低成本，如体育锻炼，以减轻这些疾病对社会至关重要。随着越来越多的证据表明 ncRNA 参与了 CVD 的发生发展，一些研究已经将这些 RNA 作为诊断和治疗的有前途的靶点。有一些关于 CVD 和 miRNAs 及 lncRNAs 作用的研究；然而，对于称为 circRNAs 的新 RNA 类知之甚少，与 CVD 有关。在这篇迷你综述中，我们重点关注 circRNAs 与 CVD 的作用机制。
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