Constituents of and Their Diuretic Activity.

Three new phenols (-), one new cyclohexanol (), two known phenols (-), and six known flavonoids (-) were isolated from the -butanol of the 75% ethanol extract of all plants of Miq. Among them, compound was named and described in its entirety for the first time, and compounds and were reported in for the first time. The structures of all compounds were confirmed using a comprehensive analysis of 1D and 2D NMR and HRESIMS data. Biological results show that compounds , , and exhibited potent diuretic activity. The modes of interaction between the selected compounds and the target diuretic-related WNK1 kinase were investigated in a preliminary molecular docking study. These results provided insight into the chemodiversity and potential diuretic activities of metabolites in .